Acquired Agranulocytosis Overview

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Learn About Acquired Agranulocytosis

What is the definition of Acquired Agranulocytosis?
Acquired agranulocytosis is a rare disorder characterized by a severe decrease in white blood cells (granulocytes) and is usually caused by drugs used to treat cancer, such as chemotherapy, and antipsychotic medications, such as clozapine, which interfere with the production of granulocytes in the bone marrow. The decrease in granulocytes makes individuals with acquired agranulocytosis more susceptible to bacteria infections from bacteria that would otherwise not be considered harmful in a healthy individual.
What are the symptoms of Acquired Agranulocytosis?
Early symptoms of acquired agranulocytosis are usually a bacterial infection that may include weakness, extreme fatigue, fever, chills, and infected ulcerations in the mucous membranes of the mouth, throat, and intestinal tract, along with difficulty swallowing (dysphagia) and irritation, pain, and swelling due to the ulcers. As the reduction in granulocytes (granulocytopenia) continues, patients with acquired agranulocytosis may develop an enlarged spleen (splenomegaly) and neutropenia (decreased blood neutrophils). In addition to the early symptoms, individuals with chronic acquired agranulocytosis may experience the development of canker sores in the mouth and gingivitis (inflammation of the gums) that regularly recurs.
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What are the current treatments for Acquired Agranulocytosis?
The standard treatment for acquired agranulocytosis is the drug, filgrastim (Neupogen), in addition to identifying and discontinuing other drugs that may be causing the disorder. Some patients with acquired agranulocytosis may require treatment with antibiotics or corticosteroid therapy for associated bacterial infections. Immunocompromised patients with acquire agranulocytosis may require gamma globulin infusions. The associated mouth and throat ulcers can be treated with saline or hydrogen peroxide gargles, anesthetic lozenges, and antifungal mouthwashes containing the drug, nystatin, for oral fungal infections, such as thrush or Candida albicans (yeast infection). A liquid diet may be necessary until the ulcers heal. Acquired agranulocytosis will usually resolve once the granulocyte levels return to normal.
Who are the top Acquired Agranulocytosis Local Doctors?
Dr. Roman Koldayev
Internal Medicine
Dr. Roman Koldayev
Internal Medicine
310 Woods Ave, Suite 3, 
Oceanside, NY 
 (5.3 mi)
718-909-7665
Languages Spoken:
English

Roman Koldayev is an Internal Medicine provider in Oceanside, New York. Dr. Koldayev and is rated as an Experienced provider by MediFind in the treatment of Acquired Agranulocytosis. His top areas of expertise are Swallowing Difficulty, Painful Swallowing, Landau-Kleffner Syndrome, and Maturity Onset Diabetes of the Young.

Ann A. Jakubowski
Dr. Ann A. Jakubowski
Hematology | Oncology
Dr. Ann A. Jakubowski
Hematology | Oncology

Mskcc Clinical Practice Plan

1275 York Ave, 
New York, NY 
 (17.9 mi)
212-639-2000
Languages Spoken:
English
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Ann Jakubowski is a Hematologist and an Oncologist in New York, New York. Dr. Jakubowski and is rated as an Advanced provider by MediFind in the treatment of Acquired Agranulocytosis. Her top areas of expertise are Acute Myeloid Leukemia (AML), Graft Versus Host Disease (GvHD), Myelodysplastic Syndrome (MDS), Acute Myeloblastic Leukemia without Maturation, and Bone Marrow Transplant.

 
 
 
 
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Morton T. Coleman
Dr. Morton T. Coleman
Hematology Oncology | Hematology
Dr. Morton T. Coleman
Hematology Oncology | Hematology
407 E 70th St, 3rd Floor, 
New York, NY 
 (18.0 mi)
212-517-5900
Languages Spoken:
English

Morton Coleman is a Hematologist Oncology specialist and a Hematologist in New York, New York. Dr. Coleman and is rated as an Advanced provider by MediFind in the treatment of Acquired Agranulocytosis. His top areas of expertise are Marginal Zone Lymphoma (MZL), Small Lymphocytic Lymphoma (SLL), Follicular Lymphoma, Bone Marrow Aspiration, and Bone Marrow Transplant.

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