The Role of Conformational Diseases on Macrophage Function
Status: Recruiting
Location: See location...
Intervention Type: Procedure, Drug
Study Type: Observational
SUMMARY
The purpose of this study is to look at how Alpha-1-antitrypsin (AAT) deficiency and Cystic Fibrosis (CF) affect white blood cells in the lungs, called macrophages, and their ability to work.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• Signed informed consent
• Male or female 18 years of age or older
• Negative pregnancy test for women of childbearing potential
• Hemoglobin \>12.5 g/dl measured on the day of participation
• Negative urine nicotine test
Locations
United States
Florida
Shands at the University of Florida
RECRUITING
Gainesville
Contact Information
Primary
Allison E. Faunce, B.A.
Allison.Faunce@medicine.ufl.edu
352-273-8666
Backup
Michelle Owens, RN, BSN
Sandra.Owens@medicine.ufl.edu
352-273-6339
Time Frame
Start Date: 2007-08-09
Estimated Completion Date: 2033-07-20
Participants
Target number of participants: 220
Treatments
AAT Deficiency
Those diagnosed with Alpha-1 Antitrypsin (AAT) Deficiency. At every study visit, a history and physical exam (H\&P), blood draw, and pulmonary function testing (PFTs) with the use of an albuterol inhaler will be done.
Cystic Fibrosis
Those diagnosed with Cystic Fibrosis (CF) with mutation Delta F508. At every study visit, a history and physical exam (H\&P), blood draw, and pulmonary function testing (PFTs) with the use of an albuterol inhaler will be done.
Without Lung Disease Diagnosis
Those without the diagnosis of AAT Deficiency or CF. At every study visit, a history and physical exam (H\&P), blood draw, and pulmonary function testing (PFTs) with the use of an albuterol inhaler will be done.
Authors
Related Therapeutic Areas
Sponsors
Leads: University of Florida