Alternating Hemiplegia of Childhood Overview

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What is the definition of Alternating Hemiplegia of Childhood?
Alternating hemiplegia of childhood (AHC) is a neurological disorder that usually affects children before 18 months of age. Classic AHC causes recurrent episodes of paralysis (hemiplegia) that involve one or both sides of the body, multiple limbs, or a single limb. The paralysis may affect different parts of the body at different times and may be brief or last for several days. A characteristic feature of AHC is that symptoms disappear during sleep and return upon waking. Many affected children display some degree of developmental delay, abnormal eye (oculomotor) movements, uncontrolled limb movements (including ataxia, dystonia, and choreoathetosis) and seizures. The majority of cases of AHC are caused by a new change (called a pathogenic variant) in the ATP1A3 gene that is not inherited. Thus, most patients with AHC do not have a family history of the disorder. A small number of cases of AHC are caused by changes in the ATP1A2 gene. When this condition does run in families, it follows an autosomal dominant pattern of inheritance.
What are the alternative names for Alternating Hemiplegia of Childhood?
  • Alternating hemiplegia of childhood
  • AHC
  • Alternating hemiplegia
  • Alternating hemiplegia syndrome
Who are the top Alternating Hemiplegia of Childhood Local Doctors?
Mohamad A. Mikati
Elite in Alternating Hemiplegia of Childhood
Dr. Mohamad A. Mikati
Pediatrics
Elite in Alternating Hemiplegia of Childhood
Dr. Mohamad A. Mikati
Pediatrics

Duke Children's Health Center Neurology Clinic

2301 Erwin Rd, 
Durham, NC 
Languages Spoken:
English, Arabic, French
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Mohamad Mikati is a Pediatrics provider in Durham, North Carolina. Dr. Mikati is rated as an Elite provider by MediFind in the treatment of Alternating Hemiplegia of Childhood. His top areas of expertise are Alternating Hemiplegia of Childhood, Epilepsy in Children, Wolf-Hirschhorn Syndrome, and Increased Head Circumference. Dr. Mikati is currently accepting new patients.

Ashley R. Helseth
Distinguished in Alternating Hemiplegia of Childhood
Dr. Ashley R. Helseth
Neurology
Distinguished in Alternating Hemiplegia of Childhood
Dr. Ashley R. Helseth
Neurology

Atrium Health Levine Children's Neurology Concord

100 Medical Park Drive, Suite 310, 
Concord, NC 
704-381-1450
Languages Spoken:
English
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Accepting New Patients
Offers Telehealth

Ashley Helseth is a Neurologist in Concord, North Carolina. Dr. Helseth is rated as a Distinguished provider by MediFind in the treatment of Alternating Hemiplegia of Childhood. Her top areas of expertise are Hemiplegia, Alternating Hemiplegia of Childhood, Status Epilepticus, and Seizures. Dr. Helseth is currently accepting new patients.

 
 
 
 
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Sujay M. Kansagra
Distinguished in Alternating Hemiplegia of Childhood
Dr. Sujay M. Kansagra
Pediatrics
Distinguished in Alternating Hemiplegia of Childhood
Dr. Sujay M. Kansagra
Pediatrics

Duke Children's Neurology Creekstone

4709 Creekstone Dr, 
Durham, NC 
Languages Spoken:
English, Gujarati 
See accepted insurances
Accepting New Patients
Offers Telehealth

Sujay Kansagra is a Pediatrics provider in Durham, North Carolina. Dr. Kansagra is rated as a Distinguished provider by MediFind in the treatment of Alternating Hemiplegia of Childhood. His top areas of expertise are Alternating Hemiplegia of Childhood, Pompe Disease, Microcephaly, and Achalasia Microcephaly Syndrome. Dr. Kansagra is currently accepting new patients.

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What are the latest Alternating Hemiplegia of Childhood Clinical Trials?
Prospective Evaluation of Atrial Fibrillation-Related Stroke Patients in Rehabilitation Program (PEARL), an Observational Cohort Study. TARGET: Health Virtual Twins for the Personalised Management of Stroke Related to Atrial Fibrillation.
Prospective Evaluation of Atrial Fibrillation-Related Stroke Patients in Rehabilitation Program (PEARL), an Observational Cohort Study. TARGET: Health Virtual Twins for the Personalised Management of Stroke Related to Atrial Fibrillation.
Enrollment Status: Recruiting
Publish Date: December 15, 2025
Intervention Type: Other

Summary: The goal of this observational study is to determine if rehabilitation program intensity impacts functional recovery and specific needs in adult ischemic stroke patients who require inpatient rehabilitation. The main questions it aims to answer are: Do patients with stroke of Atrial-related subtypes (AFRS) have distinct rehabilitation needs and functional outcomes compared to non-AFRS patients? Do...

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Effects of Inspiratory Muscle Training Via a Mobile Respiratory Trainer (AiroFit PRO™) on Pulmonary Function, Muscle Strength, and Quality of Life in Hemiplegic Individuals: A Randomized Controlled Study
Effects of Inspiratory Muscle Training Via a Mobile Respiratory Trainer (AiroFit PRO™) on Pulmonary Function, Muscle Strength, and Quality of Life in Hemiplegic Individuals: A Randomized Controlled Study
Enrollment Status: Recruiting
Publish Date: December 11, 2025
Intervention Type: Other
Study Phase: Not Applicable

Objective: To investigate and compare the efficacy of a 6-week, supervised respiratory training program using the AiroFit PRO™ mobile respiratory trainer against traditional Pursed-Lips Breathing exercises in individuals with hemiplegia. Study

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center