Antisynthetase Syndrome Overview

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Learn About Antisynthetase Syndrome

What is the definition of Antisynthetase Syndrome?
Antisynthetase syndrome is a chronic autoimmune condition that affects the muscles and various other parts of the body. The signs and symptoms can vary but may include muscle inflammation (myositis), polyarthritis (inflammation of many joints), interstitial lung disease, thickening and cracking of the hands, and Raynaud phenomenon. The exact underlying cause is unknown; however, the production of autoantibodies (antibodies that attack normal cells) that attack certain enzymes in the body called 'aminoacyl-tRNA synthetases' appears to be linked to the cause of the syndrome. These autoantibodies may arise after viral infections, or patients may have a genetic predisposition.
What are the alternative names for Antisynthetase Syndrome?
  • Antisynthetase syndrome
  • AS syndrome
  • Anti-Jo1 syndrome
Who are the top Antisynthetase Syndrome Local Doctors?
Rohit P. Aggarwal
Dr. Rohit P. Aggarwal
Rheumatology
Dr. Rohit P. Aggarwal
Rheumatology

UPMC Arthritis And Autoimmunity Center

3601 Fifth Ave, Suite 2B, 
Pittsburgh, PA 
Recognized by The Myositis Association
412-647-6700
Languages Spoken:
English, Hindi, Urdu
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Offers Telehealth

Rohit Aggarwal is a Rheumatologist in Pittsburgh, Pennsylvania. Dr. Aggarwal and is rated as an Elite provider by MediFind in the treatment of Antisynthetase Syndrome. His top areas of expertise are Myositis, Dermatomyositis, Polymyositis, and Antisynthetase Syndrome.

Miguel A. Gay-Gonzalez
Miguel A. Gay-Gonzalez
Miguel A. Gay-Gonzalez
Rheumatology Div, 
Santander And Univ. Of The Witwatersrand, ZA 

Miguel Gay-Gonzalez practices in Santander And Univ. Of The Witwatersrand, South Africa. Gay-Gonzalez and is rated as an Elite expert by MediFind in the treatment of Antisynthetase Syndrome. His top areas of expertise are Vasculitis, Temporal Arteritis, Giant Cell Arteritis (GCA), Lung Transplant, and Kidney Transplant.

 
 
 
 
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Ingrid E. Lundberg
Ingrid E. Lundberg
Rheumatology
Ingrid E. Lundberg
Rheumatology
Stockholm, AB, SE 
Recognized by The Myositis Association

Ingrid Lundberg is a Rheumatologist in Stockholm, Sweden. Lundberg and is rated as an Elite expert by MediFind in the treatment of Antisynthetase Syndrome. Her top areas of expertise are Polymyositis, Dermatomyositis, Myositis, and Inclusion Body Myositis.

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What are the latest Antisynthetase Syndrome Clinical Trials?
A Phase 2/3, Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group, 2-Arm, Multicenter, Operationally Seamless Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of Efgartigimod PH20 SC in Participants Aged 18 Years and Older with Active Idiopathic Inflammatory Myopathy
A Phase 2/3, Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group, 2-Arm, Multicenter, Operationally Seamless Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of Efgartigimod PH20 SC in Participants Aged 18 Years and Older with Active Idiopathic Inflammatory Myopathy
Enrollment Status: Recruiting
Publish Date: December 20, 2024
Intervention Type: Other, Biological
Study Phase: Phase 2/Phase 3

Summary: This study's purpose is to measure the treatment response from efgartigimod PH20 SC compared with placebo in participants with Idiopathic Inflammatory Myopathy (IIM). Participants with the IIM subtypes of dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM), or certain other subtypes of polymyositis (PM; including antisynthetase syndrome \[ASyS\]) will be included in the study. Treatm...

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Evaluation of Antigen-specific Th1 and T17 Cells, ILC and MAIT in Patients With Antisynthetase Syndrome and Interstitial Lung Disease
Evaluation of Antigen-specific Th1 and T17 Cells, ILC and MAIT in Patients With Antisynthetase Syndrome and Interstitial Lung Disease
Enrollment Status: Recruiting
Publish Date: August 27, 2024
Intervention Type: Diagnostic test

Summary: Antisynthetase syndrome (AS) is a rare overlapping myositis characterized by cellular and humoral autoimmune responses directed against aminoacyl-tRNA synthetases. Intesrtitial lung disease (ILD) is a leading cause of mortality in antisynthetase syndrome. Recently, antigen-specific IFN-γ+ CD4+ T cells have been identified in bronchoalveolar fluid (BAL) of patients with antisynthetase syndrome and ...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center