Attenuated Familial Adenomatous Polyposis Overview

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Learn About Attenuated Familial Adenomatous Polyposis

What is the definition of Attenuated Familial Adenomatous Polyposis?
Attenuated familial adenomatous polyposis (AFAP) is an inherited condition that increases the chance to develop cancer of the large intestine (colon) and rectum. It is a milder form of classic familial adenomatous polyposis (FAP). SYmptom may include colon polyps, benign or malignant tumors of the duodenum (a section of the small intestine) and, in rare cases, other symptoms of FAP. AFAP is caused by genetic changes in the APC gene and is inherited in an autosomal dominant manner.
What are the alternative names for Attenuated Familial Adenomatous Polyposis?
  • Attenuated familial adenomatous polyposis
  • AAPC
  • AFAP
  • Attenuated FAP
  • Attenuated adenomatous polyposis coli
  • Attenuated familial polyposis coli
  • Mild form of FAP
Who are the top Attenuated Familial Adenomatous Polyposis Local Doctors?
Dr. Griffith M. Thomas
General Surgery
Dr. Griffith M. Thomas
General Surgery

Ascension Seton

200 John W Hoover Pkwy, Suite A, 
Burnet, TX 
 (1.0 mi)
512-715-3046
Languages Spoken:
English, Spanish
See accepted insurances
Accepting New Patients

Griffith Thomas is a General Surgeon in Burnet, Texas. Dr. Thomas and is rated as an Advanced provider by MediFind in the treatment of Attenuated Familial Adenomatous Polyposis. His top areas of expertise are Choledocholithiasis, Hernia, Breast Cancer, Ileostomy, and Hernia Surgery. Dr. Thomas is currently accepting new patients.

Dr. Robert J. Just
Gastroenterology
Dr. Robert J. Just
Gastroenterology

Seton Family Of Doctors

201 University Oaks, Suite 1260, 
Round Rock, TX 
 (37.7 mi)
512-324-4780
Languages Spoken:
English, Spanish
See accepted insurances
Accepting New Patients
Offers Telehealth

Robert Just is a Gastroenterologist in Round Rock, Texas. Dr. Just and is rated as an Advanced provider by MediFind in the treatment of Attenuated Familial Adenomatous Polyposis. His top areas of expertise are Familial Adenomatous Polyposis, Juvenile Polyposis Syndrome, Cronkhite-Canada Disease, and Attenuated Familial Adenomatous Polyposis. Dr. Just is currently accepting new patients.

 
 
 
 
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Dr. Sooraj Tejaswi
Gastroenterology
Dr. Sooraj Tejaswi
Gastroenterology

Texas Digestive Disease Consultants PLLC

801 E Whitestone Blvd, Suite 201, 
Cedar Park, TX 
 (29.0 mi)
512-341-0900
Languages Spoken:
English
See accepted insurances

Sooraj Tejaswi is a Gastroenterologist in Cedar Park, Texas. Dr. Tejaswi and is rated as an Experienced provider by MediFind in the treatment of Attenuated Familial Adenomatous Polyposis. His top areas of expertise are Sclerosing Cholangitis, Cholangitis, Bile Duct Obstruction, Lithotripsy, and Endoscopy.

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What are the latest Attenuated Familial Adenomatous Polyposis Clinical Trials?
A Phase IIa, Placebo-Controlled, Randomized Study of Daily Obeticholic Acid (OCA) to Reduce Intestinal Polyp Burden in Familial Adenomatous Polyposis (FAP)
A Phase IIa, Placebo-Controlled, Randomized Study of Daily Obeticholic Acid (OCA) to Reduce Intestinal Polyp Burden in Familial Adenomatous Polyposis (FAP)
Who is this study for: Patients with familial adenomatous polyposis
Enrollment Status: Recruiting
Publish Date: February 21, 2025
Intervention Type: Biological, Drug, Procedure, Other
Study Drug: Obeticholic Acid
Study Phase: Phase 2

Summary: This phase IIa trial investigates if giving obeticholic acid (OCA) is safe and has a beneficial effect on the number of polyps in the small bowel and colon in patients with familial adenomatous polyposis (FAP). FAP is a rare gene defect that increases the risk of developing cancer of the intestines and colon. OCA is a drug similar to a bile acid the body makes. It is fluid made and released by the...

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center