Save information for later
Sign Up

Learn About Autosomal Dominant Hyper IgE Syndrome

What is the definition of Autosomal Dominant Hyper IgE Syndrome?
Autosomal dominant hyper IgE syndrome (AD-HIES), formerly known as Job syndrome, affects several body systems including the immune system. AD-HIES is characterized by abnormally high levels of an immune system protein called immunoglobulin E (IgE) in the blood. Signs and symptoms may include recurrent infections (e.g., pneumonia, skin infections), eczema, and occasionally bone and tooth abnormalities. The eczema and skin infections may cause rashes, blisters, collections of pus (abscesses), open sores, and scaling of the skin. Some cases of AD-HIES are caused by genetic changes in the STAT3 gene. In other cases, the cause is unknown.
What are the alternative names for Autosomal Dominant Hyper IgE Syndrome?
  • Autosomal dominant hyper IgE syndrome
  • AD hyperimmunoglobulin E syndrome
  • AD-HIES
  • HIES autosomal dominant
  • Hyper Ig E syndrome, autosomal dominant
  • Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant
  • Job syndrome autosomal dominant
Who are the top Autosomal Dominant Hyper IgE Syndrome Local Doctors?
Elite in Autosomal Dominant Hyper IgE Syndrome
Allergy and Immunology | Pediatrics
Elite in Autosomal Dominant Hyper IgE Syndrome
Allergy and Immunology | Pediatrics

Trustees Of Columbia University In The City Of New York

622 W 168th St, 
New York, NY 
 (20.1 mi)
Languages Spoken:
English
Offers Telehealth

Joshua Milner is an Allergy and Immunologist and a Pediatrics provider in New York, New York. Dr. Milner and is rated as an Elite provider by MediFind in the treatment of Autosomal Dominant Hyper IgE Syndrome. His top areas of expertise are Hyper IGE Syndrome, Autosomal Dominant Hyper IgE Syndrome, Hereditary Alpha-Tryptasemia, and Multisystem Inflammatory Syndrome in Children (MIS-C).

Distinguished in Autosomal Dominant Hyper IgE Syndrome
Pediatric Allergy and Immunology | Pediatrics
Distinguished in Autosomal Dominant Hyper IgE Syndrome
Pediatric Allergy and Immunology | Pediatrics
630 W 168th St # St1, 
New York, NY 
 (20.1 mi)
Languages Spoken:
English

Jordan Orange is a Pediatric Allergy and Immunologist and a Pediatrics provider in New York, New York. Dr. Orange and is rated as a Distinguished provider by MediFind in the treatment of Autosomal Dominant Hyper IgE Syndrome. His top areas of expertise are Common Variable Immune Deficiency, Infantile Neutropenia, Wiskott-Aldrich Syndrome, and Hyper IGE Syndrome.

 
 
 
 
Learn about our expert tiers
Learn More
Experienced in Autosomal Dominant Hyper IgE Syndrome
Family Medicine
Experienced in Autosomal Dominant Hyper IgE Syndrome
Family Medicine

Nicholas R Halper MD PC

55 Maple Ave, Suite 102, 
Rockville Centre, NY 
 (0.1 mi)
Languages Spoken:
English
Offers Telehealth

Todd Halper is a Family Medicine provider in Rockville Centre, New York. Dr. Halper and is rated as an Experienced provider by MediFind in the treatment of Autosomal Dominant Hyper IgE Syndrome. His top areas of expertise are Glucocorticoid-Remediable Aldosteronism, Familial Hypertension, Hypertension, and High Cholesterol.

What are the latest Autosomal Dominant Hyper IgE Syndrome Clinical Trials?
Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)

Summary: The Hyper IgE Syndromes (HIES) are primary immunodeficiencies resulting in eczema and recurrent skin and lung infections. Autosomal dominant Hyper IgE syndrome (AD-HIIES; Job's syndrome) is caused by STAT3 mutations, and is a multi-system disorder with skeletal, vascular, and connective tissue manifestations. Understanding how STAT3 mutations cause these diverse clinical manifestations is critical...

Match to trials
Find the right clinical trials for you in under a minute
Get started
Natural History, Genetics, Phenotype, and Treatment of Mycobacterial Infections

Summary: This study will examine the symptoms, course of disease and treatment of non-tuberculous mycobacterial (NTM) infections, as well as the genetics involved in these infections. Patients with NTM have recurrent lung infections and sometimes infections of the skin and other organs as well. They may also have curvature of the spine, barrel chest, and heart valve weakness. The study will compare the fea...

Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center