Learn About Bullous Pemphigoid
Bullous pemphigoid is a skin disorder characterized by blisters.
Bullous pemphigoid is an autoimmune disorder that occurs when the body's immune system attacks and destroys healthy body tissue by mistake. Specifically, the immune system attacks the proteins that attach the top layer of skin (epidermis) to the bottom layer of skin.
This disorder usually occurs in older persons and is rare in young people. Symptoms come and go. The condition often goes away within 5 years.
In some cases, the condition is triggered by a medicine.
Most people with this disorder have itchy skin that may be severe. In most cases, there are blisters, called bullae.
- Blisters are usually located on the arms, legs, or middle of the body. In rare cases, blisters can form in the mouth.
- The blisters may break open and form open sores (ulcers).
Anti-inflammatory medicines called corticosteroids may be prescribed. They may be taken by mouth or applied to the skin. More powerful medicines may be used to help suppress the immune system if steroids do not work, or to allow lower steroid doses to be used.
Antibiotics in the tetracycline family may be useful. Niacin (a B complex vitamin) is sometimes given along with tetracycline.
Your provider may suggest self-care measures. These may include:
- Applying anti-inflammatory creams to the skin
- Using mild soaps and applying moisturizer to the skin after bathing
- Protecting the affected skin from sun exposure and injury
Penn Dermatology Perelman
Victoria Werth is a Dermatologist in Philadelphia, Pennsylvania. Dr. Werth and is rated as an Elite provider by MediFind in the treatment of Bullous Pemphigoid. Her top areas of expertise are Cutaneous Lupus Erythematosus (CLE), Dermatomyositis, Discoid Lupus Erythematosus (DLE), and Pemphigus. Dr. Werth is currently accepting new patients.
Hideyuki Ujiie practices in Sapporo, Japan. Ujiie and is rated as an Elite expert by MediFind in the treatment of Bullous Pemphigoid. Their top areas of expertise are Bullous Pemphigoid, Bullae, Pemphigus Foliaceus, and Pemphigus Vulgaris.
Detlef Zillikens practices in Luebeck, Germany. Zillikens and is rated as an Elite expert by MediFind in the treatment of Bullous Pemphigoid. Their top areas of expertise are Epidermolysis Bullosa Acquisita, Bullous Pemphigoid, Epidermolysis Bullosa, and Bullae.
Bullous pemphigoid usually responds well to treatment. The medicine can often be stopped after several years. The disease sometimes returns after treatment is stopped.
Skin infection is the most common complication.
Complications resulting from treatment may also occur, especially from taking corticosteroids.
Contact your provider if you have:
- Unexplained blisters on your skin
- An itchy rash that continues despite home treatment
Summary: The goal of this observational study is to conduct a prospective assessment of the individual Burden of 9 rare skin diseases to assess disability in the broadest sense of the term (psychological, social, economic and physical) for patients and/or families. Two types of indicators will be used to reach this objective : 1. an individual burden score calculated based on a burden questionnaire created...
Summary: This Phase 1b basket trial will investigate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity and preliminary efficacy of RAY121, a inhibitor of classical complement pathway, after multiple dose administration in patients with immunological diseases such as antiphospholipid syndrome (APS), bullous pemphigoid (BP), Behçet's Syndrome (BS), dermatomyositis (DM), immune-medi...
Published Date: May 31, 2023
Published By: Ramin Fathi, MD, FAAD, Director, Phoenix Surgical Dermatology Group, Phoenix, AZ. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Bilgic A, Murrell DF. Bullous pemphigoid. In: Lebwohl MG, Heymann WR, Coulson IH, Murrell DF, eds. Treatment of Skin Disease: Comprehensive Therapeutic Strategies. 6th ed. Philadelphia, PA: Elsevier; 2022:chap 32.
Dinulos JGH. Vesicular and bullous diseases. In: Dinulos JGH, ed. Habif's Clinical Dermatology. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 16.