Catecholaminergic Polymorphic Ventricular Tachycardia Overview
Learn About Catecholaminergic Polymorphic Ventricular Tachycardia
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a condition characterized by an abnormal heart rhythm (arrhythmia). As the heart rate increases in response to physical activity or emotional stress, it can trigger an abnormally fast heartbeat called ventricular tachycardia. Episodes of ventricular tachycardia can cause light-headedness, dizziness, and fainting (syncope). In people with CPVT, these episodes typically begin in childhood.
CPVT most commonly results from mutations in two genes, RYR2 and CASQ2. RYR2 gene mutations cause about half of all cases, while mutations in the CASQ2 gene account for up to 5 percent of cases. Mutations in other genes are rare causes of the condition.
The prevalence of CPVT is estimated to be about 1 in 10,000 people. However, the true prevalence of this condition is unknown.
When CPVT results from mutations in the RYR2 gene, it follows an autosomal dominant inheritance pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In about half of cases, an affected person inherits an RYR2 gene mutation from one affected parent. The remaining cases result from new (de novo) mutations in the RYR2 gene that occur during the formation of reproductive cells (eggs or sperm) in an affected individual's parent or in early embryonic development. These cases occur in people with no history of the disorder in their family.
Midwest Heart And Vascular Specialists LLC
Rachel Sosland is a Cardiologist in Overland Park, Kansas. Dr. Sosland and is rated as an Experienced provider by MediFind in the treatment of Catecholaminergic Polymorphic Ventricular Tachycardia. Her top areas of expertise are Aortic Regurgitation, Pediatric Myocarditis, Necrosis, and Coronary Heart Disease. Dr. Sosland is currently accepting new patients.
Midwest Heart And Vascular Specialists LLC
Timothy Blackburn is a Cardiologist in Overland Park, Kansas. Dr. Blackburn and is rated as an Experienced provider by MediFind in the treatment of Catecholaminergic Polymorphic Ventricular Tachycardia. His top areas of expertise are Coronary Heart Disease, Atherosclerosis, Angina, and Cardiomyopathy. Dr. Blackburn is currently accepting new patients.
Midwest Heart And Vascular Specialists LLC
Theodore Pope is a Cardiologist in Overland Park, Kansas. Dr. Pope and is rated as an Experienced provider by MediFind in the treatment of Catecholaminergic Polymorphic Ventricular Tachycardia. His top areas of expertise are Aortic Regurgitation, Pediatric Myocarditis, Necrosis, and Atrial Fibrillation. Dr. Pope is currently accepting new patients.
Published Date: July 01, 2020
Published By: National Institutes of Health