Learn About Central Core Disease
Central core disease is a disorder that affects muscles used for movement (skeletal muscles). This condition causes muscle weakness that ranges from barely noticeable to very severe. The severity of muscle weakness may differ even among affected members of the same family.
Mutations in the RYR1 gene cause central core disease. The RYR1 gene provides instructions for making a protein called ryanodine receptor 1. This protein plays an essential role in skeletal muscles. For the body to move normally, these muscles must tense (contract) and relax in a coordinated way. Muscle contractions are triggered by the flow of charged atoms (ions) into muscle cells. The ryanodine receptor 1 protein forms a channel that releases calcium ions stored within muscle cells. The resulting increase in calcium ion concentration inside muscle cells stimulates muscle fibers to contract, allowing the body to move.
The exact prevalence of central core disease is unknown. However, it is thought to be the most common of the congenital myopathies, which are a group of muscle disorders that cause weakness very early in life. As a group, congenital myopathies affect 6 per 100,00 newborns.
Central core disease is most often inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In some cases, an affected person inherits the mutation from one affected parent. Other cases may result from new mutations in the gene. These cases occur in people with no history of the disorder in their family.
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Nivedita Jerath is a Neurologist in Apopka, Florida. Dr. Jerath and is rated as an Experienced provider by MediFind in the treatment of Central Core Disease. Her top areas of expertise are Charcot-Marie-Tooth Disease, Sensorimotor Polyneuropathy, Andersen-Tawil Syndrome, Rhizotomy, and Microvascular Decompression. Dr. Jerath is currently accepting new patients.
Annette Fornos is an Internal Medicine provider in Miami, Florida. Dr. Fornos and is rated as an Advanced provider by MediFind in the treatment of Central Core Disease. Her top areas of expertise are X-Linked Myotubular Myopathy, Congenital Fiber-Type Disproportion, Benign Autosomal Dominant Myopathy, and Central Core Disease. Dr. Fornos is currently accepting new patients.
Joel Silverman is an Internal Medicine provider in Boca Raton, Florida. Dr. Silverman and is rated as an Experienced provider by MediFind in the treatment of Central Core Disease. His top areas of expertise are Paraneoplastic Cerebellar Degeneration, Post-Splenectomy Syndrome, Congenital Fiber-Type Disproportion, Collagen VI-Related Myopathy, and Gastrostomy.
Summary: Core myopathies (CCD/MmD), nemaline myopathies (NEM) and centronuclear myopathies (CNM) are three types of rare congenital myopathies. Not much is known about the natural history and no curative treatment is available for these groups. Also patients report fatigability as one of their symptoms. The goal of this observational study is to study the natural history during 24 months to achieve trial r...
Summary: In the Congenital Myopathy Research Program at Boston Children's Hospital and Harvard Medical School, the researchers are studying the congenital myopathies (neuromuscular diseases present from birth), including central core disease, centronuclear/myotubular myopathy, congenital fiber type disproportion, multiminicore disease, nemaline myopathy, rigid spine muscular dystrophy, SELENON (SEPN1), RYR...
Published Date: May 01, 2020
Published By: National Institutes of Health