Chordoma Overview
Learn About Chordoma
View Main Condition: Brain Tumor
A chordoma is a rare type of cancerous tumor that can occur anywhere along the spine, from the base of the skull to the tailbone. Chordomas grow slowly, gradually extending into the bone and soft tissue around them. They often recur after treatment, and in about 40 percent of cases the cancer spreads (metastasizes) to other areas of the body, such as the lungs.
Changes in the TBXT gene have been associated with chordoma. An inherited duplication of the TBXT gene identified in a few families is associated with an increased risk of developing a chordoma. Duplications or increases in activity (expression) of the TBXT gene have also been identified in people with chordoma who have no history of the disorder in their family. In these individuals, the changes occur only in the tumor cells and are not inherited.
Chordomas are rare, occurring in approximately 1 per million individuals each year. Chordomas comprise fewer than 1 percent of tumors affecting the brain and spinal cord.
When development of a chordoma is associated with a duplication of the TBXT gene inherited from a parent, one copy of the altered gene in each cell is sufficient to increase the risk of the disorder, which is an inheritance pattern called autosomal dominant. People with this duplication inherit an increased risk of this condition, not the condition itself.
MD Anderson
Laurence Rhines is a Neurosurgery specialist and a Surgical Oncologist in Houston, Texas. Dr. Rhines is rated as an Elite provider by MediFind in the treatment of Chordoma. His top areas of expertise are Chordoma, Bone Tumor, Spinal Tumor, Osteotomy, and Vertebroplasty.
Lifespan Physician Group Inc
Ziya Gokaslan is a Neurosurgery provider in Providence, Rhode Island. Dr. Gokaslan is rated as an Elite provider by MediFind in the treatment of Chordoma. His top areas of expertise are Chordoma, Tethered Cord Syndrome, Bone Tumor, Laminectomy, and Spinal Fusion.
Memorial Solid Tumor Group
Mrinal Gounder is an Oncologist in New York, New York. Dr. Gounder is rated as an Elite provider by MediFind in the treatment of Chordoma. His top areas of expertise are Adult Soft Tissue Sarcoma, Desmoid Tumor, Epithelioid Sarcoma, Liposarcoma, and Liver Embolization.
Summary: Hematopoietic stem cell transplantation can cure patients with blood cancer and other underlying diseases. αβ-T cell and B cell depletion has been introduced to decrease GVHD and PTLD and has demonstrated effectiveness for hematologic malignancies and non-malignant diseases additionally increasing the donor pool as to allow for haploidentical transplant to safely occur. While solid tumors can be h...
Summary: The researchers are doing this study is to find out whether ERAS-601 is a safe and effective treatment that causes few or mild side effects in people with advanced and progressing chordoma.
Published Date: May 01, 2015
Published By: National Institutes of Health