Cutaneous Lupus Erythematosus (CLE) Overview

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Learn About Cutaneous Lupus Erythematosus (CLE)

What is the definition of Cutaneous Lupus Erythematosus (CLE)?
Cutaneous lupus erythematosus is a skin condition that usually occurs in individuals with systemic lupus erythematosus (SLE) but may appear before the disease becomes systemic. Systemic lupus erythematosus is an autoimmune disease in which the immune system attacks the skin, joints, kidneys, brain, and other organs. Cutaneous lupus erythematosus is categorized into three types: chronic cutaneous lupus erythematosus (CCLE), also known as discoid lupus erythematosus (DLE), subacute cutaneous lupus erythematosus (SCLE), and acute cutaneous lupus erythematosus (ACLE).
What are the symptoms of Cutaneous Lupus Erythematosus (CLE)?
Symptoms of chronic cutaneous lupus erythematosus, also known as discoid lupus erythematosus, are the appearance of disc-like lesions on the skin that are thick, scaly, block hair follicles, appear on skin exposed to the sun, and cause scarring. Symptoms of subacute cutaneous lupus erythematosus are the appearance of thick, scaly lesions on the skin that do not scar. Symptoms of acute cutaneous lupus erythematosus are lesions on the skin that are triggered by sun exposure.
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What are the current treatments for Cutaneous Lupus Erythematosus (CLE)?
Treatment for chronic cutaneous lupus erythematosus, also known as discoid lupus erythematosus, involves avoiding sun exposure; wearing Helioplex sunscreen with an SPF of 70 or higher; corticosteroid creams, ointments, and injections; anti-malarial medications, such as Plaquenil, hydroxychloroquine, or chloroquine; and/or immunosuppressive medications. Treatment for subacute cutaneous lupus erythematosus includes the use of sunscreen, wearing protective clothing when in the sun, and avoiding sun exposure. Subacute cutaneous lupus erythematosus is often resistant to treatment with steroids or anti-malarial medications. Acute cutaneous lupus erythematosus may be treated with prednisone or other immunosuppressive drugs, such as methotrexate, cyclosporine, azathioprine, or myco-phenolate mofetil.
Who are the top Cutaneous Lupus Erythematosus (CLE) Local Doctors?
Dr. Joanne C. Skaggs
Internal Medicine
Dr. Joanne C. Skaggs
Internal Medicine

Ou Health Partners Inc

940 Stanton L Young Blvd, 
Oklahoma City, OK 
 (1.4 mi)
405-271-1500
Languages Spoken:
English
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Accepting New Patients
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Joanne Skaggs is an Internal Medicine provider in Oklahoma City, Oklahoma. Dr. Skaggs and is rated as an Experienced provider by MediFind in the treatment of Cutaneous Lupus Erythematosus (CLE). Her top areas of expertise are Hypercalcemia, Idiopathic Hypercalciuria, Milk-Alkali Syndrome, and Familial Hypocalciuric Hypercalcemia Type 1. Dr. Skaggs is currently accepting new patients.

Dr. Fahed F. Hamadeh
Rheumatology
Dr. Fahed F. Hamadeh
Rheumatology

Saints Medical Group, LLC

1000 N Lee Ave, Suite 300, 
Oklahoma City, OK 
 (0.8 mi)
405-272-7000
Languages Spoken:
English, Arabic, Farsi
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Accepting New Patients
Offers Telehealth

Fahed Hamadeh is a Rheumatologist in Oklahoma City, Oklahoma. Dr. Hamadeh and is rated as a Distinguished provider by MediFind in the treatment of Cutaneous Lupus Erythematosus (CLE). His top areas of expertise are Microscopic Polyangiitis, Psoriatic Arthritis, Rheumatoid Arthritis (RA), and Psoriasis. Dr. Hamadeh is currently accepting new patients.

 
 
 
 
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Dr. Omar M. Silvestre
Rheumatology
Dr. Omar M. Silvestre
Rheumatology

Saints Medical Group, LLC

1000 N Lee Ave, 
Oklahoma City, OK 
 (0.8 mi)
Languages Spoken:
English, Spanish
See accepted insurances
Accepting New Patients
Offers Telehealth

Omar Silvestre is a Rheumatologist in Oklahoma City, Oklahoma. Dr. Silvestre and is rated as an Advanced provider by MediFind in the treatment of Cutaneous Lupus Erythematosus (CLE). His top areas of expertise are Rheumatoid Arthritis (RA), Undifferentiated Connective Tissue Disease (UCTD), Sjogren Syndrome, and Psoriatic Arthritis. Dr. Silvestre is currently accepting new patients.

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What are the latest Cutaneous Lupus Erythematosus (CLE) Clinical Trials?
A 2-Part Seamless Part A (Phase 2)/Part B (Phase 3) Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of BIIB059 in Participants With Active Subacute Cutaneous Lupus Erythematosus and/or Chronic Cutaneous Lupus Erythematosus With or Without Systemic Manifestations and Refractory and/or Intolerant to Antimalarial Therapy (AMETHYST)
A 2-Part Seamless Part A (Phase 2)/Part B (Phase 3) Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of BIIB059 in Participants With Active Subacute Cutaneous Lupus Erythematosus and/or Chronic Cutaneous Lupus Erythematosus With or Without Systemic Manifestations and Refractory and/or Intolerant to Antimalarial Therapy (AMETHYST)
Enrollment Status: Recruiting
Publish Date: February 14, 2025
Intervention Type: Drug
Study Phase: Phase 2/Phase 3

Summary: In this study, researchers will learn more about a study drug called litifilimab (BIIB059) in participants with cutaneous lupus erythematosus (CLE). The study will focus on participants who have either active subacute CLE or chronic CLE, or both. They may also have systemic lupus erythematosus (SLE). The participants did not respond to antimalarial therapy or had problems with the treatment that m...

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A Multicenter, Randomized, Double Blind, Placebo Controlled, Phase III Study to Evaluate the Efficacy and Safety of Anifrolumab in Adults With Chronic and/or Subacute Cutaneous Lupus Erythematosus Who Are Refractory and/or Intolerant to Antimalarial Therapy
A Multicenter, Randomized, Double Blind, Placebo Controlled, Phase III Study to Evaluate the Efficacy and Safety of Anifrolumab in Adults With Chronic and/or Subacute Cutaneous Lupus Erythematosus Who Are Refractory and/or Intolerant to Antimalarial Therapy
Enrollment Status: Recruiting
Publish Date: January 29, 2025
Intervention Type: Combination product, Other
Study Phase: Phase 3

Summary: This study aims to evaluate the efficacy and safety of subcutaneous (SC) anifrolumab versus placebo in adult participants with cutaneous lupus erythematosus (CLE).

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