Learn About Desmoid Tumor

What is the definition of Desmoid Tumor?

A desmoid tumor is an abnormal growth that arises from connective tissue, which is the tissue that provides strength and flexibility to structures such as bones, ligaments, and muscles. Typically, a single tumor develops, although some people have multiple tumors. The tumors can occur anywhere in the body. Tumors that form in the abdominal wall are called abdominal desmoid tumors; those that arise from the tissue that connects the abdominal organs are called intra-abdominal desmoid tumors; and tumors found in other regions of the body are called extra-abdominal desmoid tumors. Extra-abdominal tumors occur most often in the shoulders, upper arms, and upper legs.

What are the causes of Desmoid Tumor?

Mutations in the CTNNB1 gene or the APC gene cause desmoid tumors. CTNNB1 gene mutations account for around 85 percent of sporadic desmoid tumors. APC gene mutations cause desmoid tumors associated with familial adenomatous polyposis as well as 10 to 15 percent of sporadic desmoid tumors. Both genes are involved in an important cell signaling pathway that controls the growth and division (proliferation) of cells and the process by which cells mature to carry out specific functions (differentiation).

How prevalent is Desmoid Tumor?

Desmoid tumors are rare, affecting an estimated 1 to 2 per 500,000 people worldwide. In the United States, 900 to 1,500 new cases are diagnosed per year. Sporadic desmoid tumors are more common than those associated with familial adenomatous polyposis.

Is Desmoid Tumor an inherited disorder?

Most desmoid tumors are sporadic and are not inherited. Sporadic tumors result from gene mutations that occur during a person's lifetime, called somatic mutations. A somatic mutation in one copy of the gene is sufficient to cause the disorder. Somatic mutations in either the CTNNB1 or the APC gene can cause sporadic desmoid tumors.

Who are the top Desmoid Tumor Local Doctors?
Orthopedics
Orthopedics

Stony Brook Orthopaedic Associates, University Faculty Practice Corpor

14 Technology Dr, 
East Setauket, NY 
 (3.4 mi)
Languages Spoken:
English
Offers Telehealth

Fazel Khan is an Orthopedics provider in East Setauket, New York. Dr. Khan and is rated as a Distinguished provider by MediFind in the treatment of Desmoid Tumor. His top areas of expertise are Bone Tumor, Congenital Generalized Fibromatosis, Infantile Myofibromatosis, Hip Replacement, and Osteotomy.

Radiology | Radiation Oncology | Interventional Radiology
Radiology | Radiation Oncology | Interventional Radiology

John T Mather Memorial Hospital

75 N Country Rd, 
Port Jefferson, NY 
 (0.9 mi)
Languages Spoken:
English

Mohammad Bilal is a Radiologist and a Radiation Oncologist in Port Jefferson, New York. Dr. Bilal and is rated as an Experienced provider by MediFind in the treatment of Desmoid Tumor. His top areas of expertise are Ascites, Thyroid Hormone Plasma Membrane Transport Defect, Familial Hyperthyroidism due to Mutations in TSH Receptor, Vertebroplasty, and Bone Graft.

 
 
 
 
Learn about our expert tiers
Learn More
Oncology | Pain Medicine | Hematology Oncology
Oncology | Pain Medicine | Hematology Oncology

North Shore Hematology Oncology Associates PC

1500 Route 112, 
Port Jefferson Station, NY 
 (3.0 mi)
Languages Spoken:
English

Giuseppe Condemi is an Oncologist and a Pain Medicine provider in Port Jefferson Station, New York. Dr. Condemi and is rated as an Experienced provider by MediFind in the treatment of Desmoid Tumor. His top areas of expertise are Familial Colorectal Cancer, Colorectal Cancer, Paget Disease of the Breast, and Breast Cancer.

What are the latest Desmoid Tumor Clinical Trials?
The TNT Protocol: A Phase 2 Study Using Talimogene Laherparepvec,Nivolumab and Trabectedin as First, Second/Third Line Therapy for Advanced Sarcoma, Including Desmoid Tumor and Chordoma

Summary: This is a Phase 2 study using talimogene laherparepvec, nivolumab, and trabectedin as first, second or third line therapy for advanced sarcoma, including desmoid tumor and chordoma.

Match to trials
Find the right clinical trials for you in under a minute
Get started
The Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study

Summary: This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.

Who are the sources who wrote this article ?

Published Date: March 01, 2013
Published By: National Institutes of Health