Diffuse Midline Glioma H3 K27M-Mutant Overview

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Learn About Diffuse Midline Glioma H3 K27M-Mutant

View Main Condition: Brain Tumor

What is the definition of Diffuse Midline Glioma H3 K27M-Mutant?
Diffuse intrinsic pontine glioma (DIPG) is a type of aggressive brain tumor that occurs in the pons, part of the brainstem. The pons is important for many bodily functions, including regulating breathing, heart rate, bladder control, balance, and more.  Diffuse intrinsic pontine glioma primarily affects children, with roughly 150-300 new diagnoses per year. 
What are the causes of Diffuse Midline Glioma H3 K27M-Mutant?
The cause of diffuse intrinsic pontine glioma is not currently known. Research is being done to identify if certain genetic mutations may be causing DIPG. 
What are the symptoms of Diffuse Midline Glioma H3 K27M-Mutant?
Symptoms of diffuse intrinsic pontine glioma often develop quickly. Symptoms may include poor coordination, arm and leg weakness, as well as difficulty controlling eye movements and facial expressions. Some individuals may experience difficulty speaking or eating as well. 
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What are the current treatments for Diffuse Midline Glioma H3 K27M-Mutant?
The main treatments for diffuse intrinsic pontine glioma currently include radiation therapy and experimental chemotherapy.  Radiation therapy is generally used for newly diagnosed DIPG. Radiation therapy involves the use of high-energy beams, including X-rays or protons, to destroy tumor cells. Various clinical trials have shown that routine chemotherapy is not effective for treating DIPG. Newer treatments combine chemotherapy with biologic therapy that directly target the tumor.  Because of the tumor's location in the brainstem, it is rarely possible to perform surgery without risk of causing neurological damage. 
Who are the top Diffuse Midline Glioma H3 K27M-Mutant Local Doctors?
Experienced in Diffuse Midline Glioma H3 K27M-Mutant
Dr. Jigarkumar Parikh
Hematology Oncology | Hematology | Oncology
Experienced in Diffuse Midline Glioma H3 K27M-Mutant
Dr. Jigarkumar Parikh
Hematology Oncology | Hematology | Oncology

Wellstar Medical Group, LLC

1350 Walton Way, 
Augusta, GA 
 (2.6 mi)
706-721-8623
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Jigarkumar Parikh is a Hematologist Oncology specialist and a Hematologist in Augusta, Georgia. Dr. Parikh and is rated as an Experienced provider by MediFind in the treatment of Diffuse Midline Glioma H3 K27M-Mutant. His top areas of expertise are Adult Soft Tissue Sarcoma, Clear Cell Sarcoma, WT1-Related Wilms Tumor Syndromes, Bone Marrow Aspiration, and Endoscopy.

Experienced in Diffuse Midline Glioma H3 K27M-Mutant
Dr. Samuel D. Macomson
Neurosurgery
Experienced in Diffuse Midline Glioma H3 K27M-Mutant
Dr. Samuel D. Macomson
Neurosurgery

Wellstar Medical Group, LLC

1120 15th St, 
Augusta, GA 
 (2.2 mi)
706-721-8623
Languages Spoken:
English, Spanish
See accepted insurances
Accepting New Patients
Offers Telehealth

Samuel Macomson is a Neurosurgery provider in Augusta, Georgia. Dr. Macomson and is rated as an Experienced provider by MediFind in the treatment of Diffuse Midline Glioma H3 K27M-Mutant. His top areas of expertise are Hydrocephalus Autosomal Recessive, Hydrocephalus Skeletal Anomalies, Subdural Hematoma, and Brain Herniation. Dr. Macomson is currently accepting new patients.

 
 
 
 
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Experienced in Diffuse Midline Glioma H3 K27M-Mutant
Dr. Suzanne H. Smith
Neurology
Experienced in Diffuse Midline Glioma H3 K27M-Mutant
Dr. Suzanne H. Smith
Neurology

Wellstar Medical Group, LLC

1120 15th St, 
Augusta, GA 
 (2.2 mi)
706-721-8623
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Suzanne Smith is a Neurologist in Augusta, Georgia. Dr. Smith and is rated as an Experienced provider by MediFind in the treatment of Diffuse Midline Glioma H3 K27M-Mutant. Her top areas of expertise are Relapsing Multiple Sclerosis (RMS), Multiple Sclerosis (MS), Myotonic Dystrophy Type 2, and Myotonic Dystrophy. Dr. Smith is currently accepting new patients.

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What is the outlook (prognosis) for Diffuse Midline Glioma H3 K27M-Mutant?
The prognosis for diffuse intrinsic pontine glioma is very poor. Although there is no cure, a small percentage of patients survive.
What are the latest Diffuse Midline Glioma H3 K27M-Mutant Clinical Trials?
A Phase I Study of Savolitinib in Recurrent, Progressive or Refractory Medulloblastoma, High-Grade Glioma, Diffuse Intrinsic Pontine Glioma, and CNS Tumors Harboring MET Aberrations
A Phase I Study of Savolitinib in Recurrent, Progressive or Refractory Medulloblastoma, High-Grade Glioma, Diffuse Intrinsic Pontine Glioma, and CNS Tumors Harboring MET Aberrations
Who is this study for: Patients with recurrent, progressive or refractory medulloblastoma, high-grade glioma, diffuse intrinsic pontine glioma, and CNS tumors harboring MET aberrations
Enrollment Status: Recruiting
Publish Date: February 26, 2025
Intervention Type: Procedure, Drug
Study Drug: Savolitinib
Study Phase: Phase 1

Summary: This phase I trial studies the side effects and best dose of volitinib in treating patients with primary central nervous system (CNS) tumors that have come back (recurrent) or does not respond to treatment (refractory). Volitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

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Phase 2 Study of Olutasidenib with Temozolomide As Maintenance Therapy in Pediatric and Young Adult Patients Newly Diagnosed with High-Grade Glioma (HGG), Including Diffuse Intrinsic Pontine Glioma (DIPG), Which Harbor IDH1 Mutations
Phase 2 Study of Olutasidenib with Temozolomide As Maintenance Therapy in Pediatric and Young Adult Patients Newly Diagnosed with High-Grade Glioma (HGG), Including Diffuse Intrinsic Pontine Glioma (DIPG), Which Harbor IDH1 Mutations
Enrollment Status: Recruiting
Publish Date: February 21, 2025
Intervention Type: Drug
Study Phase: Phase 2

Summary: The goal of this study is to determine the efficacy of the study drug olutasidenib to treat newly diagnosed pediatric and young adult patients with a high-grade glioma (HGG) harboring an IDH1 mutation. The main question the study aims to answer is whether the combination of olutasidenib and temozolomide (TMZ) can prolong the life of patients diagnosed with an IDH-mutant HGG.

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What are some Advocacy Organizations?
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Keep Punching supports patients, healthcare providers, and researchers in their fight to prevent and eradicate brain cancer and minimize treatment-related side effects that may adversely impact function and comfort.