Esophageal atresia coloboma talipes is a birth defect that consists of the following three conditions: Esophageal atresia is a birth defect in which the esophagus (swallowing tube connecting the mouth to the stomach) did not develop properly. Instead of a connected esophagus, in infants with esophageal atresia the esophagus is separated into two sections. Esophageal atresia often occurs with another birth defect, tracheoesophageal fistula, in which a section of the esophagus is connected to the trachea (windpipe). Coloboma is a birth defect in which normal tissue in or around the eye is missing. Coloboma can affect one or both eyes, either similarly of differently, depending on the part of the eye affected, including the eyelid, lens, macula, optic nerve, uvea, or retina. Talipes, also known as clubfoot, is a birth defect in which an infant’s foot is twisted out of shape or position due to the tendons being too short. Talipes can be mild or severe and occur in one or both feet.

Symptoms of esophageal atresia appear directly after birth and include an inability to pass food from the mouth to the stomach, difficulty breathing, frothy white bubbles in the mouth, coughing or choking when feeding, and bluish color of the skin (cyanosis). Symptoms of a coloboma depend on its location and may include a keyhole or cat-eye pupil (iris), a notch defect in the eyelid, visual problems, and sensitivity to light. Symptoms of talipes may include a foot that is twisted and inward or severely turned as to appear upside down, a shorter leg or foot than the unaffected side, and underdeveloped calf muscles.

Treatment for esophageal atresia includes nutrition, medication, and surgery. Treatment for coloboma depends on its location and may include colored contract lenses, eye patches, eye drops, low vision devices, and surgery. Treatment for talipes begins in the first week after birth and includes stretching, casting, and weekly repositioning (Ponseti method), special shoes and braces, or surgery.