Fibrous Dysplasia Overview
Learn About Fibrous Dysplasia
Fibrous dysplasia is a bone disease that destroys and replaces normal bone with fibrous bone tissue. One or more bones can be affected.
Inflammatory fibrous hyperplasia; Idiopathic fibrous hyperplasia; McCune-Albright syndrome
Fibrous dysplasia usually occurs in childhood. Most people have symptoms by the time they are 30 years old. The disease occurs more often in females.
Fibrous dysplasia is linked to a problem with genes (gene mutation) that control bone-producing cells. The mutation occurs when a baby is developing in the womb. The condition is not passed from parent to child.
Symptoms may include any of the following:
- Bone pain
- Bone sores (lesions)
- Hormone (endocrine gland) problems
- Fractures or bone deformities
- Unusual skin color (pigmentation), which occurs with McCune-Albright syndrome
The bone lesions may stop when the child reaches puberty.
There is no cure for fibrous dysplasia. Bone fractures or deformities are treated as needed. Hormone problems will need to be treated.
Premier Therapy And Health Centers Inc
Felix Cheung is an Orthopedics provider in Grayson, Kentucky. Dr. Cheung and is rated as a Distinguished provider by MediFind in the treatment of Fibrous Dysplasia. His top areas of expertise are Osteochondroma, Hemangiopericytoma, Fibrous Dysplasia, Knee Replacement, and Hip Replacement. Dr. Cheung is currently accepting new patients.
Osu Internal Medicine LLC
Joel Mayerson is an Orthopedics provider in Columbus, Ohio. Dr. Mayerson and is rated as an Advanced provider by MediFind in the treatment of Fibrous Dysplasia. His top areas of expertise are Adult Soft Tissue Sarcoma, Bone Tumor, Liposarcoma, Hip Replacement, and Osteotomy. Dr. Mayerson is currently accepting new patients.
Osu Internal Medicine LLC
Luma Ghalib is an Endocrinologist in Columbus, Ohio. Dr. Ghalib and is rated as an Experienced provider by MediFind in the treatment of Fibrous Dysplasia. Her top areas of expertise are Hypothalamic Tumor, Pituitary Tumor, Rathke Cleft Cyst, and Prolactinoma. Dr. Ghalib is currently accepting new patients.
The outlook depends on the severity of the condition and the symptoms that occur.
Depending on the bones that are affected, health problems that may result include:
- If skull bone is affected, there can be vision or hearing loss
- If a leg bone is affected, there can be difficulty walking and joint problems such as arthritis
Contact your provider if your child has symptoms of this condition, such as repeated bone fractures and unexplained bone deformity.
Specialists in orthopedics, endocrinology, and genetics may be involved in your child's diagnosis and care.
There is no known way to prevent fibrous dysplasia. Treatment aims to prevent complications, such as recurrent bone fractures, to help make the condition less severe.
Summary: Polyostotic fibrous dysplasia (PFD) is a sporadic disorder which affects multiple sites in the skeleton. The bone at these sites is rapidly resorbed and replaced by abnormal fibrous tissue or mechanically abnormal bone. PFD may occur alone or as part of the McCune-Albright Syndrome (MAS), a syndrome originally defined by the triad of PFD, cafe-au-lait pigmentation of the skin, and precocious puber...
Summary: Fibrous Dysplasia/McCune-Albright syndrome (FD/MAS) is a rare disease, consisting of the replacement of normal bone tissue with fibrous tissue. FD lesions may be isolated in one or more bones or may be associated with endocrinopathies in McCune-Albright syndrome. Bone lesions constitute of weak bone tissue, leading to higher risk of fractures, pain and decreased quality of life. There is no cure f...
Published Date: November 06, 2023
Published By: Neil K. Kaneshiro, MD, MHA, Clinical Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Nadol JB, Quesnel AM. Otologic manifestations of systemic disease. In: Flint PW, Francis HW, Haughey BH, et al, eds. Cummings Otolaryngology: Head and Neck Surgery. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 151.
Nicolai P, Mattavelli D, Castlenuovo P. Benign tumors of the sinonasal tract. In: Flint PW, Francis HW, Haughey BH, et al, eds. Cummings Otolaryngology: Head and Neck Surgery. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 50.
Shiflett JM, Caroll BW. Skull lesions in children. In: Winn HR, ed. Youmans and Winn Neurological Surgery. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 245.
Toy PC, Heck RK. Benign bone tumors and nonneoplastic conditions simulating bone tumors. In: Azar FM, Beaty JH, eds. Campbell's Operative Orthopaedics. 14th ed. Philadelphia, PA: Elsevier; 2021:chap 25.