Generalized Resistance to Thyroid Hormone Overview

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What is the definition of Generalized Resistance to Thyroid Hormone?
Generalized resistance to thyroid hormone (GRTH), is a rare genetic condition characterized by hyperthyroidism (overactive thyroid) and reduced body tissue response to thyroid hormone.
What are the symptoms of Generalized Resistance to Thyroid Hormone?
Some individuals with generalized resistance to thyroid hormone may not have any symptoms. Symptoms of generalized resistance to thyroid hormone may include goiter (swelling of the neck), rapid heartbeat (tachycardia), delayed bone maturation, osteoporosis, growth retardation, short stature, mental retardation, recurrent ear infections, sensorineural deafness, repetitive, uncontrolled eye movements (nystagmus), learning disabilities, and attention deficit hyperactivity disorder (ADHD).
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What are the current treatments for Generalized Resistance to Thyroid Hormone?
There is no cure for generalized resistance to thyroid hormone. Because individuals with this disorder have increased blood levels of T4 and T3 thyroid hormones, treatment is usually not necessary. However, when treatment for goiter, rapid heartbeat, or tremor associated with generalized resistance to thyroid hormone are necessary, the thyroid hormone medication, liothyronine (T3) or the beta adrenergic blocker, atenolol may be prescribed. Attention deficit hyperactivity disorder associated with generalized resistance to thyroid hormone is treated with the usual medications. Some individuals with generalized resistance to thyroid hormone may also be prescribed the thyroid hormone, levothyroxine (T4).
Who are the top Generalized Resistance to Thyroid Hormone Local Doctors?
Dr. Michael Walker
Endocrinology
Dr. Michael Walker
Endocrinology

Albany Medical College

1365 Washington Ave, 
Albany, NY 
 (8.4 mi)
518-262-5196
Languages Spoken:
English
See accepted insurances

Michael Walker is an Endocrinologist in Albany, New York. Dr. Walker and is rated as an Experienced provider by MediFind in the treatment of Generalized Resistance to Thyroid Hormone. His top areas of expertise are Hypothyroidism, Obesity in Children, Maturity Onset Diabetes of the Young, and Type 2 Diabetes (T2D).

Dr. Gary Bakst
Endocrinology
Dr. Gary Bakst
Endocrinology

Albany Medical College

1365 Washington Ave, 
Albany, NY 
 (8.4 mi)
518-262-5196
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Gary Bakst is an Endocrinologist in Albany, New York. Dr. Bakst and is rated as an Experienced provider by MediFind in the treatment of Generalized Resistance to Thyroid Hormone. His top areas of expertise are Hypothalamic Tumor, Osteoporosis, Postmenopausal Osteoporosis, and Type 2 Diabetes (T2D).

 
 
 
 
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Dr. Vibhavasu Sharma
Endocrinology | Geriatrics
Dr. Vibhavasu Sharma
Endocrinology | Geriatrics

Albany Medical College

47 New Scotland Ave, 
Albany, NY 
 (9.2 mi)
518-262-5633
Languages Spoken:
English
See accepted insurances

Vibhavasu Sharma is an Endocrinologist and a Geriatrics provider in Albany, New York. Dr. Sharma and is rated as an Experienced provider by MediFind in the treatment of Generalized Resistance to Thyroid Hormone. His top areas of expertise are Addison's Disease, Secondary Adrenal Insufficiency, Maturity Onset Diabetes of the Young, Triple A Syndrome, and Thyroidectomy.

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What are the latest Generalized Resistance to Thyroid Hormone Clinical Trials?
Deep Geno- and Phenotyping of Patients With Thyroid Hormone Resistance, a Register Study.
Deep Geno- and Phenotyping of Patients With Thyroid Hormone Resistance, a Register Study.
Enrollment Status: Recruiting
Publish Date: August 22, 2024
Intervention Type: Other

Summary: Thyroid hormones (TH) play a pivotal role in the development and function of the mammalian brain. Patients with impaired thyroid hormone transport into the brain tissue or in the case of defective local thyroid hormone receptor (collectively referred to as thyroid hormone resistance) subsequently experience psychomotor disabilities. The DEEPTYPE registry has been established with the objective of ...

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Advancing Understanding, Diagnosis and Monitoring of Thyroid Hormone Action Defects (ADAM-THAD)
Advancing Understanding, Diagnosis and Monitoring of Thyroid Hormone Action Defects (ADAM-THAD)
Enrollment Status: Recruiting
Publish Date: March 13, 2024
Intervention Type: Genetic, Diagnostic test

Summary: The goal of this observational study is to learn about the neurological and cardiological phenotype of patients with resistance to thyroid hormone (RTH) syndromes beta and alpha (RTHß and RTHa) due to dominant negative variants in the genes encoding the thyroid hormone receptors alpha (THRA) and beta (THRB). The main question\[s\] it aims to answer are: * Define frequency and improve early diagnos...

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