Generalized Resistance to Thyroid Hormone Overview

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What is the definition of Generalized Resistance to Thyroid Hormone?
Generalized resistance to thyroid hormone (GRTH), is a rare genetic condition characterized by hyperthyroidism (overactive thyroid) and reduced body tissue response to thyroid hormone.
What are the symptoms of Generalized Resistance to Thyroid Hormone?
Some individuals with generalized resistance to thyroid hormone may not have any symptoms. Symptoms of generalized resistance to thyroid hormone may include goiter (swelling of the neck), rapid heartbeat (tachycardia), delayed bone maturation, osteoporosis, growth retardation, short stature, mental retardation, recurrent ear infections, sensorineural deafness, repetitive, uncontrolled eye movements (nystagmus), learning disabilities, and attention deficit hyperactivity disorder (ADHD).
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What are the current treatments for Generalized Resistance to Thyroid Hormone?
There is no cure for generalized resistance to thyroid hormone. Because individuals with this disorder have increased blood levels of T4 and T3 thyroid hormones, treatment is usually not necessary. However, when treatment for goiter, rapid heartbeat, or tremor associated with generalized resistance to thyroid hormone are necessary, the thyroid hormone medication, liothyronine (T3) or the beta adrenergic blocker, atenolol may be prescribed. Attention deficit hyperactivity disorder associated with generalized resistance to thyroid hormone is treated with the usual medications. Some individuals with generalized resistance to thyroid hormone may also be prescribed the thyroid hormone, levothyroxine (T4).
Who are the top Generalized Resistance to Thyroid Hormone Local Doctors?
Distinguished in Generalized Resistance to Thyroid Hormone
Dr. Alexandra M. Dumitrescu
Endocrinology
Distinguished in Generalized Resistance to Thyroid Hormone
Dr. Alexandra M. Dumitrescu
Endocrinology

University Of Chicago

355 E Grand Ave, 
Chicago, IL 
 (1.1 mi)
888-824-0200
Languages Spoken:
English
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Accepting New Patients
Offers Telehealth

Alexandra Dumitrescu is an Endocrinologist in Chicago, Illinois. Dr. Dumitrescu and is rated as a Distinguished provider by MediFind in the treatment of Generalized Resistance to Thyroid Hormone. Her top areas of expertise are Allan-Herndon-Dudley Syndrome, Generalized Resistance to Thyroid Hormone, Familial Hyperthyroidism due to Mutations in TSH Receptor, Hypothyroidism, and Hormone Replacement Therapy (HRT). Dr. Dumitrescu is currently accepting new patients.

Advanced in Generalized Resistance to Thyroid Hormone
Dr. Allison Hahr
Endocrinology
Advanced in Generalized Resistance to Thyroid Hormone
Dr. Allison Hahr
Endocrinology

Northwestern Medical Faculty Foundation

1333 W Belmont Ave, 
Chicago, IL 
 (4.6 mi)
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Allison Hahr is an Endocrinologist in Chicago, Illinois. Dr. Hahr and is rated as an Advanced provider by MediFind in the treatment of Generalized Resistance to Thyroid Hormone. Her top areas of expertise are Osteoporosis, Postmenopausal Osteoporosis, Melorheostosis with Osteopoikilosis, and Osteopenia.

 
 
 
 
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Experienced in Generalized Resistance to Thyroid Hormone
Dr. Catherine J. Yi
Internal Medicine
Experienced in Generalized Resistance to Thyroid Hormone
Dr. Catherine J. Yi
Internal Medicine

Northwestern Medical Faculty Foundation

675 N Saint Clair St, 
Chicago, IL 
 (1.2 mi)
Languages Spoken:
English, Korean
See accepted insurances
Accepting New Patients
Offers Telehealth

Catherine Yi is an Internal Medicine provider in Chicago, Illinois. Dr. Yi and is rated as an Experienced provider by MediFind in the treatment of Generalized Resistance to Thyroid Hormone. Her top areas of expertise are Alopecia Areata, Autosomal Recessive Hypotrichosis, Urethritis, and Vertigo. Dr. Yi is currently accepting new patients.

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What are the latest Generalized Resistance to Thyroid Hormone Clinical Trials?
Deep Geno- and Phenotyping of Patients With Thyroid Hormone Resistance, a Register Study.
Deep Geno- and Phenotyping of Patients With Thyroid Hormone Resistance, a Register Study.
Enrollment Status: Recruiting
Publish Date: August 22, 2024
Intervention Type: Other

Summary: Thyroid hormones (TH) play a pivotal role in the development and function of the mammalian brain. Patients with impaired thyroid hormone transport into the brain tissue or in the case of defective local thyroid hormone receptor (collectively referred to as thyroid hormone resistance) subsequently experience psychomotor disabilities. The DEEPTYPE registry has been established with the objective of ...

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Advancing Understanding, Diagnosis and Monitoring of Thyroid Hormone Action Defects (ADAM-THAD)
Advancing Understanding, Diagnosis and Monitoring of Thyroid Hormone Action Defects (ADAM-THAD)
Enrollment Status: Recruiting
Publish Date: March 13, 2024
Intervention Type: Genetic, Diagnostic test

Summary: The goal of this observational study is to learn about the neurological and cardiological phenotype of patients with resistance to thyroid hormone (RTH) syndromes beta and alpha (RTHß and RTHa) due to dominant negative variants in the genes encoding the thyroid hormone receptors alpha (THRA) and beta (THRB). The main question\[s\] it aims to answer are: * Define frequency and improve early diagnos...

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