Genetic Epilepsy with Febrile Seizures Plus (GEFS+) Overview
Learn About Genetic Epilepsy with Febrile Seizures Plus (GEFS+)
Genetic epilepsy with febrile seizures plus (GEFS+) is a spectrum of seizure disorders of varying severity. GEFS+ is usually diagnosed in families whose members have a combination of febrile seizures, which are triggered by a high fever, and recurrent seizures (epilepsy) of other types, including seizures that are not related to fevers (afebrile seizures). The additional seizure types usually involve both sides of the brain (generalized seizures); however, seizures that involve only one side of the brain (partial seizures) occur in some affected individuals. The most common types of seizure in people with GEFS+ include myoclonic seizures, which cause involuntary muscle twitches; atonic seizures, which involve sudden episodes of weak muscle tone; and absence seizures, which cause loss of consciousness for short periods that appear as staring spells.
Mutations in several genes, including some that have not been identified, can cause GEFS+. The most commonly associated gene is SCN1A. More than 80 percent of Dravet syndrome cases and about 10 percent of other GEFS+ cases are caused by changes in this gene. Mutations in other genes have been found in only a small number of affected individuals or families.
GEFS+ is a rare condition. Its prevalence is unknown.
GEFS+ is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.
Shlomo Shinnar is a Pediatric Neurologist and a Neurologist in Bronx, New York. Dr. Shinnar and is rated as an Elite provider by MediFind in the treatment of Genetic Epilepsy with Febrile Seizures Plus (GEFS+). His top areas of expertise are Genetic Epilepsy with Febrile Seizures Plus (GEFS+), Status Epilepticus, Seizures, and Epilepsy.
New York University
Orrin Devinsky is a Neurologist and a General Surgeon in New York, New York. Dr. Devinsky and is rated as a Distinguished provider by MediFind in the treatment of Genetic Epilepsy with Febrile Seizures Plus (GEFS+). His top areas of expertise are Myoclonic Epilepsy, Seizures, Dravet Syndrome, Epilepsy, and Deep Brain Stimulation.
Montefiore Medical Center
Solomon Moshe is a Pediatric Neurologist and a Neurologist in Bronx, New York. Dr. Moshe and is rated as a Distinguished provider by MediFind in the treatment of Genetic Epilepsy with Febrile Seizures Plus (GEFS+). His top areas of expertise are West Syndrome, Spasmus Nutans, Post-Traumatic Epilepsy, and Epilepsy.
Summary: This is a prospective, randomized, open-label clinical trial to evaluate the safety of COVID-19 vaccination and other routine childhood vaccines given simultaneously at Visit 1, as compared to sequential vaccination of COVID-19 vaccine and other vaccines at separate visits (Visits 1 and 2).
Summary: Febrile seizures are considered a very common syndrome presented in the pediatric emergency room. Witnessing these seizures may can cause anxiety in parents and generate them psychological sequelae such as major depressive disorder in the short term, or sleep disorders in the long term. An appropriate care for parents must be put in place in the emergency department, with the objective of improvin...
Published Date: July 01, 2017
Published By: National Institutes of Health