Heart Failure with Preserved Ejection Fraction (HFpEF) Overview

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Learn About Heart Failure with Preserved Ejection Fraction (HFpEF)

What is the definition of Heart Failure with Preserved Ejection Fraction (HFpEF)?
Heart failure with preserved ejection fraction is a syndrome wherein the left ventricle of the heart is unable to relax normally between each heartbeat. This leads to an increase in blood pressure in the left ventricle when blood fills it between each heartbeat. An ejection fraction measures how well the heart pumps blood. In heart failure with preserved ejection fraction, while there is heart failure the ejection fraction is normal.
What are the symptoms of Heart Failure with Preserved Ejection Fraction (HFpEF)?
Symptoms of heart failure with preserved ejection fraction include shortness of breath, especially when lying flat; chest discomfort; fatigue; exercise intolerance; abdominal swelling; and lower leg swelling.
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What are the current treatments for Heart Failure with Preserved Ejection Fraction (HFpEF)?
Treatment for heart failure with preserved ejection fraction includes treating high blood pressure with medications, diuretics, and cardiac revascularization.
Who are the top Heart Failure with Preserved Ejection Fraction (HFpEF) Local Doctors?
Dalane W. Kitzman
Elite in Heart Failure with Preserved Ejection Fraction (HFpEF)
Dr. Dalane W. Kitzman
Cardiology
Elite in Heart Failure with Preserved Ejection Fraction (HFpEF)
Dr. Dalane W. Kitzman
Cardiology

Wake Forest University Health Sciences

4618 Country Club Rd, 
Winston Salem, NC 
336-716-3926
Languages Spoken:
English
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Accepting New Patients

Dalane Kitzman is a Cardiologist in Winston Salem, North Carolina. Dr. Kitzman is rated as an Elite provider by MediFind in the treatment of Heart Failure with Preserved Ejection Fraction (HFpEF). His top areas of expertise are Heart Failure with Preserved Ejection Fraction (HFpEF), Heart Failure, Atherosclerosis, and Cardiomyopathy. Dr. Kitzman is currently accepting new patients.

Robert J. Mentz
Elite in Heart Failure with Preserved Ejection Fraction (HFpEF)
Dr. Robert J. Mentz
Advanced Heart Failure and Transplant Cardiology | Cardiology | Transplant Surgery
Elite in Heart Failure with Preserved Ejection Fraction (HFpEF)
Dr. Robert J. Mentz
Advanced Heart Failure and Transplant Cardiology | Cardiology | Transplant Surgery

Duke Cardiology Clinic - Clinic 2F/2G

40 Duke Medicine Cir, 
Durham, NC 
919-681-5816
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Robert Mentz is an Advanced Heart Failure and Transplant Cardiologist and a Cardiologist in Durham, North Carolina. Dr. Mentz is rated as an Elite provider by MediFind in the treatment of Heart Failure with Preserved Ejection Fraction (HFpEF). His top areas of expertise are Heart Failure, Heart Failure with Preserved Ejection Fraction (HFpEF), Low Blood Pressure, Heart Transplant, and Endoscopy. Dr. Mentz is currently accepting new patients.

 
 
 
 
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Elite in Heart Failure with Preserved Ejection Fraction (HFpEF)
Dr. Sheldon E. Litwin
Advanced Heart Failure and Transplant Cardiology | Cardiology
Elite in Heart Failure with Preserved Ejection Fraction (HFpEF)
Dr. Sheldon E. Litwin
Advanced Heart Failure and Transplant Cardiology | Cardiology

University Medical Associates Of The Medical University Of South Carol

171 Ashley Ave, 
Charleston, SC 
843-792-1414
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Sheldon Litwin is an Advanced Heart Failure and Transplant Cardiologist and a Cardiologist in Charleston, South Carolina. Dr. Litwin is rated as an Elite provider by MediFind in the treatment of Heart Failure with Preserved Ejection Fraction (HFpEF). His top areas of expertise are Heart Failure with Preserved Ejection Fraction (HFpEF), Heart Failure, Cardiomyopathy, Gastric Bypass, and Cardiac Ablation. Dr. Litwin is currently accepting new patients.

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What are the latest Heart Failure with Preserved Ejection Fraction (HFpEF) Clinical Trials?
A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Enrollment Status: Recruiting
Publish Date: December 17, 2025
Intervention Type: Drug, Other
Study Phase: Phase 1

Summary: A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants with Heart Failure with Preserved Ejection Fraction (HFpEF)

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A Phase 2A, Double-blind, Randomized, Placebo-controlled, Multi-center Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
A Phase 2A, Double-blind, Randomized, Placebo-controlled, Multi-center Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Enrollment Status: Recruiting
Publish Date: December 15, 2025
Intervention Type: Other, Drug
Study Phase: Phase 2

Summary: The purpose of this study is to evaluate the safety, tolerability, and exposure-response (E-R) of BMS-986435/MYK-224 in participants with symptomatic Heart Failure with Preserved Ejection Fraction (HFpEF).

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