Hidradenitis Suppurativa Overview
Learn About Hidradenitis Suppurativa
Hidradenitis suppurativa, also known as acne inversa, is a chronic skin disease characterized by recurrent boil-like lumps (nodules) under the skin. The nodules become inflamed and painful. They tend to break open (rupture), causing abscesses that drain fluid and pus. As the abscesses heal, they produce significant scarring of the skin.
In most cases, the cause of hidradenitis suppurativa is unknown. The condition probably results from a combination of genetic and environmental factors. Originally, researchers believed that the disorder was caused by the blockage (occlusion) of specialized sweat glands called apocrine glands. However, recent studies have shown that the condition actually begins with a blockage of hair follicles in areas of the body that also contain a high concentration of apocrine glands (such as the armpits and groin). The hair follicles have a buildup of a fibrous protein called keratin (hyperkeratosis). The blocked hair follicles trap bacteria, leading to inflammation and rupture. Researchers have several ideas about what initially causes the follicles to become blocked and why the nodules tend to recur, but the causes remain unclear.
Hidradenitis suppurativa was once thought to be a rare condition because only the most severe cases were reported. However, recent studies have shown that the condition affects at least 1 in 100 people when milder cases are also considered. For reasons that are unclear, women are more commonly affected than men.
Hidradenitis suppurativa has been reported to run in families. Studies have found that 30 to 40 percent of affected individuals have at least one family member with the disorder. However, this finding may be an underestimate because affected individuals do not always tell their family members that they have the condition, and hidradenitis suppurativa is sometimes misdiagnosed as other skin disorders.
Florida Hospital Physician Group Inc
Mark Casebolt is a General Surgeon in Ocala, Florida. Dr. Casebolt and is rated as an Experienced provider by MediFind in the treatment of Hidradenitis Suppurativa. His top areas of expertise are Peptic Ulcer, Cellulitis, Necrosis, Hernia Surgery, and Small Bowel Resection. Dr. Casebolt is currently accepting new patients.
Sheila Torres is a Dermatologist in Lady Lake, Florida. Dr. Torres and is rated as an Experienced provider by MediFind in the treatment of Hidradenitis Suppurativa. Her top areas of expertise are Universal Acquired Melanosis, Liver Spots, Psoriasis, and Actinic Keratosis.
Midstate Skin Institute LLC
Ashley Cauthen is a Dermatologist in Ocala, Florida. Dr. Cauthen and is rated as an Experienced provider by MediFind in the treatment of Hidradenitis Suppurativa. Her top areas of expertise are Plaque Psoriasis, Sunburn, Psoriasis, and Actinic Keratosis.
Summary: Hidradenitis suppurativa (HS) is a chronic and often painful inflammatory skin disease which includes the forming of lumps, abscesses and scars in areas of the skin such as under the breasts, under armpits, inner thighs, groin and buttocks. This study will compare lutikizumab versus placebo for the treatment of adult and adolescent participants with moderate to severe HS . Lutikizumab is an invest...
Summary: This study aims to find the appropriately safe and effective dose and dosing frequency for eltrekibart in adults with moderate-to-severe hidradenitis suppurativa (HS) for further clinical development. The study will last approximately 62 weeks and may include up to 31 visits.
Published Date: October 27, 2021
Published By: National Institutes of Health