Learn About Kaposi Sarcoma
Kaposi sarcoma (KS) is a cancerous tumor of the connective tissue.
Kaposi's sarcoma; HIV - Kaposi; AIDS - Kaposi; Kaposi's sarcoma
KS is the result of infection with a gamma herpesvirus known as Kaposi sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV8). It is in the same family as the Epstein-Barr virus, which causes mononucleosis.
KSHV is transmitted mainly through saliva. It can also be spread through sexual contact, blood transfusion, or transplants. After it enters the body, the virus can infect different kinds of cells, especially cells that line blood vessels and lymphatic vessels. Like all herpesviruses, KSHV remains in your body for the rest of your life. If your immune system becomes weakened in the future, this virus may have the chance to reactivate, causing symptoms.
There are four types of KS based on the groups of people who are infected:
- Classic KS: Mainly affects older men of Eastern European, Middle Eastern, and Mediterranean descent. The disease usually develops slowly.
- Epidemic (AIDS-related) KS: Occurs most often in people who have HIV infection and have developed AIDS.
- Endemic (African) KS: Mainly affects people of all ages in Africa.
- Immunosuppression-associated, or transplantation-associated, KS: Occurs in people who have had an organ transplant and take medicines that suppress their immune system.
The tumors (lesions) most often appear as bluish-red or purple bumps on the skin. They are reddish-purple because they are rich in blood vessels.
The lesions may first appear on any part of the body. They also can appear inside the body. Lesions inside the body may bleed. Lesions in the lungs can cause bloody sputum or shortness of breath.
How KS is treated depends on:
- How much the immune system is suppressed (immunosuppression)
- Number and location of the tumors
- Symptoms
Treatments include:
- Antiviral therapy against HIV, since there is no specific therapy for HHV-8
- Combination chemotherapy
- Freezing the lesions
- Radiation therapy
Lesions may return after treatment.
Lucia Brambilla practices in Milan, Italy. Brambilla and is rated as an Elite expert by MediFind in the treatment of Kaposi Sarcoma. Her top areas of expertise are Kaposi Sarcoma, Adult Soft Tissue Sarcoma, Cherry Angioma, Erosive Pustular Dermatosis of the Scalp, and Hip Replacement.
Matthias Egger practices in Bern, Switzerland. Egger and is rated as an Elite expert by MediFind in the treatment of Kaposi Sarcoma. His top areas of expertise are HIV/AIDS, Kaposi Sarcoma, Aspergillosis, and Adult Soft Tissue Sarcoma.
Jackson Orem practices in Kampala, Uganda. Orem and is rated as an Elite expert by MediFind in the treatment of Kaposi Sarcoma. His top areas of expertise are Burkitt Lymphoma, Kaposi Sarcoma, B-Cell Lymphoma, Tissue Biopsy, and Gastrostomy.
Treating KS does not improve the chances of survival from HIV/AIDS itself. The outlook depends on the person's immune status and how much of the HIV virus is in their blood (viral load). If the HIV is controlled with medicine, the lesions will often shrink away on their own.
Complications can include:
- Cough (possibly bloody) and shortness of breath if the disease is in the lungs
- Leg swelling that may be painful or cause infections if the disease is in the lymph nodes of the legs
The tumors can return even after treatment. KS can be deadly for a person with AIDS.
An aggressive form of endemic KS can spread quickly to the bones. Another form found in African children does not affect the skin. Instead, it spreads through the lymph nodes and vital organs, and can quickly become deadly.
Safer sexual practices can prevent HIV infection. This prevents HIV/AIDS and its complications, including KS.
KS almost never occurs in people with HIV/AIDS whose disease is well controlled.
Background: Kaposi sarcoma herpesvirus (KSHV)-associated inflammatory cytokine syndrome (KICS) and KSHV-multicentric Castleman disease (MCD) occur in people living with HIV. These diseases cause severe inflammation that can be fatal if not treated.
Background: Kaposi Sarcoma (KS) is common in people with human immunodeficiency virus (HIV) but can also occur in people who do not have HIV. KS tumors usually involve the skin, but may also involve lymph nodes, lungs, bone, and gastrointestinal tract. Researchers want to see if a drug that is currently used to treat a type of breast cancer can help.
Published Date: December 04, 2022
Published By: Jatin M. Vyas, MD, PhD, Associate Professor in Medicine, Harvard Medical School; Associate in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Kaye KM. Kaposi sarcoma-associated herpesvirus (human herpesvirus 8). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 140.
Merrick ST, Jones S, Glesby MJ. Systemic manifestations of HIV/AIDS. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 366.
National Cancer Institute website. Kaposi sarcoma treatment (PDQ) - health professional version. www.cancer.gov/types/soft-tissue-sarcoma/hp/kaposi-treatment-pdq. Updated September 23, 2022. Accessed January 2, 2023.