Klippel-Trenaunay Syndrome Overview
Learn About Klippel-Trenaunay Syndrome
Klippel-Trenaunay syndrome (KTS) is a rare condition that is typically present at birth. The syndrome often involves port wine stains, excess growth of bones and soft tissue, and varicose veins.
Klippel-Trenaunay-Weber syndrome; KTS; Angio-osteohypertrophy; Hemangiectasia hypertrophicans; Nevus verucosus hypertrophicans; Capillary-lymphatico-venous malformation (CLVM)
KTS is caused by a genetic variation that occurs during fetal development. Why this occurs is unknown.
Symptoms of KTS include:
- Many port wine stains or other blood vessel problems, including dark spots on the skin
- Varicose veins (may be seen in early infancy, but are more likely to be seen later in childhood or adolescence)
- Unstable gait due to limb-length difference (involved limb is longer)
- Bone, vein, or nerve pain
Other possible symptoms:
- Bleeding from the rectum
- Blood in the urine
More information and support for people with KTS and their families can be found at:
- The Klippel-Trenaunay Syndrome Support Group -- k-t.org
- Vascular Birthmarks Foundation -- birthmark.org
Most people with KTS do well, although the condition may affect their appearance.
Novant Health Medical Group, LLC
Eboni Ellis-Farabee is a Family Medicine provider in Charlotte, North Carolina. Dr. Ellis-Farabee has been practicing medicine for over 16 years and is rated as an Advanced provider by MediFind in the treatment of Klippel-Trenaunay Syndrome. Her top areas of expertise are Rubinstein-Taybi Syndrome, Nail-Patella Syndrome, Parkes Weber Syndrome, and VACTERL Association. Dr. Ellis-Farabee is currently accepting new patients.
Charlotte Radiology PA
Vittorio Antonacci is a Radiologist and an Interventional Radiologist in Matthews, North Carolina. Dr. Antonacci and is rated as an Experienced provider by MediFind in the treatment of Klippel-Trenaunay Syndrome. His top areas of expertise are Ascites, Familial Pancreatic Cancer, Urothelial Cancer, Endoscopy, and Gastrostomy. Dr. Antonacci is currently accepting new patients.
University Of North Carolina At Chapel Hill
Patricia Chang is an Advanced Heart Failure and Transplant Cardiologist and a Cardiologist in Hillsborough, North Carolina. Dr. Chang and is rated as a Distinguished provider by MediFind in the treatment of Klippel-Trenaunay Syndrome. Her top areas of expertise are Heart Failure, Atherosclerosis, Klippel-Trenaunay Syndrome, Heart Transplant, and Splenectomy. Dr. Chang is currently accepting new patients.
Summary: Lymphatic anomalies are a rare subset of vascular anomalies that are poorly understood. the understanding of the natural history, long-term outcomes, risk factors for morbidity and mortality, and the relative benefit of medical therapies and procedures is limited.The goal of this project is to better understand these diseases and improve the care of theses rare patients. To do this, the investigat...
Summary: The study will use blood (serum and plasma) and tissue obtained from participants undergoing prescribed surgical resection of vascular anomalies of interest proposed in this study. The study will also use blood (serum and plasma) and tissue collected and stored in a tissue bank maintained by the Department of Hematology/Oncology.
Published Date: December 31, 2023
Published By: Anna C. Edens Hurst, MD, MS, Associate Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Greene AK, Mulliken JB. Vascular anomalies. In: Losee JE, Hopper RA, eds. Plastic Surgery: Volume 3: Craniofacial, Head and Neck Surgery and Pediatric Plastic Surgery. 5th ed. Philadelphia, PA: Elsevier; 2024:chap 31.
K-T Support Group website. Clinical practice guidelines for Klippel-Trenaunay syndrome (KTS). k-t.org/assets/images/content/BCH-Klippel-Trenaunay-Syndrome-Management-Guidelines-1-6-2016.pdf. Updated January 6, 2016. Accessed April 18, 2024.
Longman RE. Klippel-Trenaunay-Weber syndrome. In: Copel JA, D'Alton ME, Feltovich H, et al, eds. Obstetric Imaging: Fetal Diagnosis and Care. 2nd ed. Philadelphia, PA: Elsevier; 2018:chap 131.
McCormick AA, Grundwaldt LJ. Vascular anomalies. In: Zitelli BJ, McIntire SC, Nowalk AJ, Garrison J, eds. Zitelli and Davis' Atlas of Pediatric Physical Diagnosis. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 10.