Langerhans Cell Histiocytosis Overview
Learn About Langerhans Cell Histiocytosis
Langerhans cell histiocytosis is a disorder in which excess immune system cells called Langerhans cells build up in the body. Langerhans cells, which help regulate the immune system, are normally found throughout the body, especially in the skin, lymph nodes, spleen, lungs, liver, and bone marrow. In Langerhans cell histiocytosis, excess immature Langerhans cells usually form tumors called granulomas. Many researchers now consider Langerhans cell histiocytosis to be a form of cancer, but this classification remains controversial.
Somatic mutations in the BRAF gene have been identified in the Langerhans cells of about half of individuals with Langerhans cell histiocytosis. Somatic gene mutations are acquired during a person's lifetime and are present only in certain cells. These changes are not inherited.
Langerhans cell histiocytosis is a rare disorder. Its prevalence is estimated at 1 to 2 in 100,000 people.
Langerhans cell histiocytosis is usually not inherited and typically occurs in people with no history of the disorder in their family.
Memorial Hospital At Gulfport
Pamela Tuli is a Hematologist Oncology specialist and a Hematologist in Biloxi, Mississippi. Dr. Tuli and is rated as an Advanced provider by MediFind in the treatment of Langerhans Cell Histiocytosis. Her top areas of expertise are Lynch Syndrome, Colorectal Cancer, Familial Colorectal Cancer, Lung Adenocarcinoma, and Bone Marrow Aspiration. Dr. Tuli is currently accepting new patients.
Jeffrey Schwartz is a Pediatric Hematologist Oncology specialist and a Hematologist in Pensacola, Florida. Dr. Schwartz and is rated as an Experienced provider by MediFind in the treatment of Langerhans Cell Histiocytosis. His top areas of expertise are Acute Lymphoblastic Leukemia (ALL), Leukemia, Infantile Neutropenia, and Dyserythropoietic Anemia and Thrombocytopenia. Dr. Schwartz is currently accepting new patients.
Lolie Yu is a Pediatric Hematologist Oncology specialist and a Pediatrics provider in New Orleans, Louisiana. Dr. Yu and is rated as an Advanced provider by MediFind in the treatment of Langerhans Cell Histiocytosis. Her top areas of expertise are Severe Combined Immunodeficiency (SCID), Hepatoblastoma, Ependymoma, Bone Marrow Transplant, and Bone Marrow Aspiration. Dr. Yu is currently accepting new patients.
Summary: This phase II trial tests the safety, side effects, best dose and activity of tovorafenib (DAY101) in treating patients with Langerhans cell histiocytosis that is growing, spreading, or getting worse (progressive), has come back (relapsed) after previous treatment, or does not respond to therapy (refractory). Langerhans cell histiocytosis is a type of disease that occurs when the body makes too ma...
Summary: This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.
Published Date: October 01, 2017
Published By: National Institutes of Health