Ledderhose Disease Overview

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Learn About Ledderhose Disease

What is the definition of Ledderhose Disease?
Ledderhose disease is a type of plantar fibromatosis characterized by the growth of hard and round or flattened nodules (lumps) on the soles of the feet. It typically affects both feet and progresses slowly, but not indefinitely. The nodules are often painless at first, but may cause pain when walking as they grow. People with Ledderhose disease may also have other conditions associated with the formation of excess fibrous connective tissue such as Dupuytren contracture, knuckle pads, or Peyronie disease. Repeated trauma, long-term alcohol consumption, chronic liver disease, diabetes, and epilepsy have also been reported in association with this condition. The exact cause of Ledderhose disease is not known, but heredity is thought to play a role in many cases.
What are the alternative names for Ledderhose Disease?
  • Ledderhose disease
  • Lederhose disease
Who are the top Ledderhose Disease Local Doctors?
Christopher J. Pappas
Distinguished in Ledderhose Disease
Dr. Christopher J. Pappas
Podiatric Medicine | Podiatric Surgery
Distinguished in Ledderhose Disease
Dr. Christopher J. Pappas
Podiatric Medicine | Podiatric Surgery

Pappas Podiatry

1619 N 9th St, #6, 
Stroudsburg, PA 
570-534-0311
Languages Spoken:
English
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Accepting New Patients
Offers Telehealth

Christopher Pappas is a Podiatric Medicine specialist and a Podiatric Surgeon in Stroudsburg, Pennsylvania. Dr. Pappas and is rated as a Distinguished provider by MediFind in the treatment of Ledderhose Disease. His top areas of expertise are Achilles Tendon Rupture, Fibromatosis, Plantar Fasciitis, and Ledderhose Disease. Dr. Pappas is currently accepting new patients.

Distinguished in Ledderhose Disease
Dr. Michael W. Seiberg
Podiatric Medicine | Podiatric Surgery
Distinguished in Ledderhose Disease
Dr. Michael W. Seiberg
Podiatric Medicine | Podiatric Surgery
39000 Bob Hope Dr, Harry & Diane Rinker Building, 
Rancho Mirage, CA 
760-568-2684
Languages Spoken:
English
See accepted insurances

Michael Seiberg is a Podiatric Medicine specialist and a Podiatric Surgeon in Rancho Mirage, California. Dr. Seiberg and is rated as a Distinguished provider by MediFind in the treatment of Ledderhose Disease. His top areas of expertise are Ingrown Toenail, Ledderhose Disease, Plantar Fasciitis, and Fibromatosis.

 
 
 
 
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Distinguished in Ledderhose Disease
Dr. Brian G. Ralph
Podiatric Medicine
Distinguished in Ledderhose Disease
Dr. Brian G. Ralph
Podiatric Medicine

Roper Saint Francis Physicians Network

8950 University Blvd, 
North Charleston, SC 
Languages Spoken:
English
See accepted insurances
Accepting New Patients

Brian Ralph is a Podiatric Medicine provider in North Charleston, South Carolina. Dr. Ralph and is rated as a Distinguished provider by MediFind in the treatment of Ledderhose Disease. His top areas of expertise are Hammer Toe, Plantar Fasciitis, Ledderhose Disease, and Fibromatosis. Dr. Ralph is currently accepting new patients.

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What are the latest Ledderhose Disease Clinical Trials?
A Phase 3, Double-blind, Randomized, Placebo-controlled Study to Assess the Efficacy, Safety, and Tolerability of EN3835 vs Placebo in the Treatment of Plantar Fibromatosis (PFI) (Also Known as Ledderhose Disease)
A Phase 3, Double-blind, Randomized, Placebo-controlled Study to Assess the Efficacy, Safety, and Tolerability of EN3835 vs Placebo in the Treatment of Plantar Fibromatosis (PFI) (Also Known as Ledderhose Disease)
Enrollment Status: Recruiting
Publish Date: March 05, 2025
Intervention Type: Biological, Other
Study Phase: Phase 3

Summary: This study will assess the efficacy, safety, and tolerability of EN3835 compared to placebo in the treatment of PFI (also known as Ledderhose disease).

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center