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Learn About Mast Cell Activation Syndrome (MCAS)

What is the definition of Mast Cell Activation Syndrome (MCAS)?
Mast cell activation syndrome (MCAS) causes a person to have repeated severe allergy symptoms affecting several body systems. In MCAS, mast cells mistakenly release too many chemical agents, resulting in symptoms in the skin, gastrointestinal tract, heart, respiratory, and neurologic systems. Mast cells are present throughout most of our bodies and secrete different chemicals during allergic reactions. Symptoms include episodes of abdominal pain, cramping, diarrhea, flushing, itching, wheezing, coughing, lightheadedness and rapid pulse and low blood pressure. Symptoms can start at any age, but usually begin in adulthood. The cause of MCAS is unknown. Diagnosis is based on the symptoms, clinical exam, and specific laboratory testing. Other conditions may need to be excluded before MCAS can be diagnosed.
What are the alternative names for Mast Cell Activation Syndrome (MCAS)?
  • Mast cell activation syndrome
  • MCAS
Who are the top Mast Cell Activation Syndrome (MCAS) Local Doctors?
Hematology Oncology | Hematology | Oncology
Hematology Oncology | Hematology | Oncology

MD Anderson

1515 Holcombe Blvd, 
Houston, TX 
 (105.8 mi)
Languages Spoken:
English
Offers Telehealth

Prithviraj Bose is a Hematologist Oncology specialist and a Hematologist in Houston, Texas. Dr. Bose and is rated as an Elite provider by MediFind in the treatment of Mast Cell Activation Syndrome (MCAS). His top areas of expertise are Myelofibrosis, Essential Thrombocythemia, Leukemia, Bone Marrow Aspiration, and Bone Marrow Transplant.

Oncology | Hematology Oncology
Oncology | Hematology Oncology
1515 Holcombe Blvd, 
Houston, TX 
 (105.8 mi)
Languages Spoken:
English

Srdan Verstovsek is an Oncologist and a Hematologist Oncology provider in Houston, Texas. Dr. Verstovsek and is rated as a Distinguished provider by MediFind in the treatment of Mast Cell Activation Syndrome (MCAS). His top areas of expertise are Myelofibrosis, Essential Thrombocythemia, Polycythemia Vera, Bone Marrow Aspiration, and Bone Marrow Transplant.

 
 
 
 
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University Of Texas Health Science Center At San Antonio

7979 Wurzbach Rd, 
San Antonio, TX 
 (133.3 mi)
Languages Spoken:
English
Accepting New Patients

Robyn Scherber is a Hematologist in San Antonio, Texas. Dr. Scherber and is rated as a Distinguished provider by MediFind in the treatment of Mast Cell Activation Syndrome (MCAS). Her top areas of expertise are Myeloproliferative Neoplasms (MPN), Polycythemia Vera, Myelofibrosis, Essential Thrombocythemia, and Bone Marrow Transplant. Dr. Scherber is currently accepting new patients.

What are the latest Mast Cell Activation Syndrome (MCAS) Clinical Trials?
An Open-label, Multicenter, Rollover Study in Patients Who Participated in an Avapritinib Clinical Study

Summary: The primary objective of the rollover study is to evaluate the long-term safety of avapritinib in participants who have completed a Blueprint Medicines sponsored study (parent study) and continued to benefit from avapritinib.

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A Phase 1 Study of Avapritinib in Combination With Decitabine in Patients With Systemic Mastocytosis With an Associated Hematologic Neoplasm (SM-AHN)

Summary: Systemic mastocytosis with an associated hematologic neoplasm (SM-AHN) is a challenging disease to treat. Targeted KIT inhibitors have been approved for this indication based on their ability to control the mastocytosis portion of the disease, but patients frequently experience progression of the concomitant myeloid malignancy (i.e. the AHN). Using a combination approach to treat both aspects of t...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center