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Learn About Mayer-Rokitansky-Kuster-Hauser Syndrome

What is the definition of Mayer-Rokitansky-Kuster-Hauser Syndrome?

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a disorder that mainly affects the female reproductive system. This condition causes the vagina and uterus to be underdeveloped or absent, although external genitalia are normal. Affected individuals usually do not have menstrual periods due to the absence of a uterus. Often, the first noticeable sign of MRKH syndrome is that menstruation does not begin by age 16 (primary amenorrhea). People with MRKH syndrome have a female chromosome pattern (46,XX) and normally functioning ovaries. They also have normal breast and pubic hair development. Although people with this condition are usually unable to carry a pregnancy, they may be able to have children through assisted reproduction.

What are the causes of Mayer-Rokitansky-Kuster-Hauser Syndrome?

The cause of MRKH syndrome is unknown. Changes in several genes that are involved in development before birth have been identified in people with MRKH syndrome. However, each has been found in only a few affected individuals, and it is unclear whether these changes cause MRKH syndrome. Researchers are working to determine how genetic changes might lead to problems with development of the female reproductive system.

How prevalent is Mayer-Rokitansky-Kuster-Hauser Syndrome?

MRKH syndrome affects approximately 1 in 4,500 female newborns.

Is Mayer-Rokitansky-Kuster-Hauser Syndrome an inherited disorder?

Most cases of MRKH syndrome occur in people with no history of the disorder in their family.

Who are the top Mayer-Rokitansky-Kuster-Hauser Syndrome Local Doctors?
Obstetrics and Gynecology
Obstetrics and Gynecology

Duke Health Integrated Practice Inc

2301 Erwin Rd, 
Durham, NC 
 (9.3 mi)
Languages Spoken:
English, Spanish
Accepting New Patients
Offers Telehealth

Cassandra Kisby is an Obstetrics and Gynecologist in Durham, North Carolina. Dr. Kisby and is rated as an Experienced provider by MediFind in the treatment of Mayer-Rokitansky-Kuster-Hauser Syndrome. Her top areas of expertise are Uterine Prolapse, Stress Urinary Incontinence, Urinary Incontinence, and Mayer-Rokitansky-Kuster-Hauser Syndrome. Dr. Kisby is currently accepting new patients.

Obstetrics and Gynecology | Reproductive Medicine
Obstetrics and Gynecology | Reproductive Medicine
1350 S Kings Dr, 
Charlotte, NC 
 (111.7 mi)
Languages Spoken:
English
Accepting New Patients

Ashley Eskew is an Obstetrics and Gynecologist and a Reproductive Medicine provider in Charlotte, North Carolina. Dr. Eskew and is rated as an Experienced provider by MediFind in the treatment of Mayer-Rokitansky-Kuster-Hauser Syndrome. Her top areas of expertise are Infertility, Kuster Syndrome, Mayer-Rokitansky-Kuster-Hauser Syndrome, Intrauterine Device Insertion, and Oophorectomy. Dr. Eskew is currently accepting new patients.

 
 
 
 
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What are the latest Mayer-Rokitansky-Kuster-Hauser Syndrome Clinical Trials?
Uterus Transplantation From Live Donors and From Deceased Donors - Clinical Study

Summary: Uterus transplantation (UTx) is the only causative treatment for congenital or acquired uterus absence. Individual cases of UTx from a live donor (LD UTx) with healthy child birth performed so far showed favourable outcomes. The present study will include both LD UTx and UTx from deceased donors after brain death (DBD UTx). The aim is treatment of uterine infertility by UTx. It is is an ethically ...

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Published Date: June 23, 2022
Published By: National Institutes of Health