Methemoglobinemia Overview
Learn About Methemoglobinemia
Methemoglobinemia (MetHb) is a blood disorder in which an abnormal amount of methemoglobin is produced. Hemoglobin is the protein in red blood cells (RBCs) that carries and distributes oxygen to the body. Methemoglobin is a form of hemoglobin.
With methemoglobinemia, the hemoglobin can carry oxygen, but is not able to release it effectively to body tissues.
Hemoglobin M disease; Erythrocyte reductase deficiency; Generalized reductase deficiency; MetHb
The MetHb condition can be:
- Passed down through families (inherited or congenital)
- Caused by exposure to certain medicines, chemicals, or foods (acquired)
There are two forms of inherited MetHb. The first form is passed on by both parents due to genetic variants in both. The parents usually do not have the condition themselves. They carry the gene that causes the condition. It occurs when there is a problem with an enzyme called cytochrome b5 reductase.
There are two types of inherited MetHb:
- Type 1 (also called erythrocyte reductase deficiency) occurs when RBCs lack the enzyme.
- Type 2 (also called generalized reductase deficiency) occurs when the enzyme doesn't work in the body.
The second form of inherited MetHb is called hemoglobin M disease. It is caused by defects in the hemoglobin protein itself. Only one parent needs to pass on the variant gene for the child to inherit the disease.
Acquired MetHb is more common than the inherited forms. It occurs in some people after they are exposed to certain chemicals and medicines, including:
- Anesthetics such as benzocaine
- Nitrobenzene
- Certain antibiotics (including dapsone and chloroquine)
- Nitrites (used as additives to prevent meat from spoiling)
Symptoms of type 1 MetHb include:
- Bluish coloring of the skin (called cyanosis)
Symptoms of type 2 MetHb include:
- Developmental delay
- Failure to thrive
- Intellectual disability
- Seizures
Symptoms of hemoglobin M disease include:
- Bluish coloring of the skin
Symptoms of acquired MetHb include:
- Bluish coloring of the skin
- Headache
- Giddiness
- Altered mental state
- Fatigue
- Shortness of breath
- Lack of energy
People with hemoglobin M disease don't have symptoms. So, they may not need treatment.
A medicine called methylene blue is used to treat severe MetHb. Methylene blue may be unsafe in people who have or may be at risk for a blood disease called G6PD deficiency. They should not take this medicine. If you or your child has G6PD deficiency, always tell your provider before getting treatment.
Ascorbic acid may also be used to reduce the level of methemoglobin.
Alternative treatments include hyperbaric oxygen therapy, red blood cell transfusion and exchange transfusions.
In most cases of mild acquired MetHb, no treatment is needed. But you should avoid the medicine or chemical that caused the problem. Severe cases may need a blood transfusion.
Gary Proffett is a Geriatrics specialist and a General Practice provider in Rancho Mirage, California. Dr. Proffett and is rated as an Advanced provider by MediFind in the treatment of Methemoglobinemia. His top areas of expertise are Anemia, Maturity Onset Diabetes of the Young, Familial Hypertension, and Hypertension.
Jason Domagalski is a Family Medicine provider in Palm Springs, California. Dr. Domagalski and is rated as an Experienced provider by MediFind in the treatment of Methemoglobinemia. His top areas of expertise are Acquired Methemoglobinemia, Hypothermia, Methemoglobinemia, and Volkmann Contracture. Dr. Domagalski is currently accepting new patients.
Armaity Austin is a Family Medicine provider in Los Angeles, California. Dr. Austin and is rated as an Experienced provider by MediFind in the treatment of Methemoglobinemia. Her top areas of expertise are Type 2 Diabetes (T2D), Methemoglobinemia, Hypertension, and Familial Hypertension.
People with type 1 MetHb and hemoglobin M disease often do well. Type 2 MetHb is more serious. It often causes death within the first few years of life.
People with acquired MetHb often do very well once the medicine, food, or chemical that caused the problem is identified and avoided.
Complications of MetHb include:
- Shock
- Seizures
- Death
Contact your provider if you:
- Have a family history of MetHb
- Develop symptoms of this disorder
Call 911 or the local emergency number right away if you have severe shortness of breath.
Genetic counseling is suggested for couples with a family history of MetHb and are considering having children.
Babies 6 months or younger are more likely to develop methemoglobinemia. Therefore, homemade baby food purees made from vegetables containing high levels of natural nitrates, such as carrots, beetroots, or spinach should be avoided.
Summary: Methemoglobinemia as a side effect of treatment with intravenous iron has not previously been described. This study aims to assess methemoglobin levels in patients with anemia following treatment with intravenous iron, administered as ferric carboxymaltose or ferric derisomaltose.
Published Date: June 17, 2024
Published By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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Means Jr RT. Approach to the anemias. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 144.
Owusu-Ansah A, Letterio J, Ahuja SP. Red blood cell disorders in the fetus and neonate. In: Martin RJ, Fanaroff AA, eds. Fanaroff and Martin's Neonatal-Perinatal Medicine. 12th ed. Philadelphia, PA: Elsevier; 2025:chap 81.