Microcephalic Osteodysplastic Primordial Dwarfism Type 1 (MOPD1) Overview

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Learn About Microcephalic Osteodysplastic Primordial Dwarfism Type 1 (MOPD1)

View Main Condition: Short Stature (Growth Disorders)

What is the definition of Microcephalic Osteodysplastic Primordial Dwarfism Type 1 (MOPD1)?
Microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1) is a genetic condition that is mainly characterized by intrauterine and post-natal growth retardation; an abnormally small head size (microcephaly); abnormal bone growth (skeletal dysplasia); distinctive facial features; and brain anomalies. Other signs and symptoms include sparse hair and eyebrows; dry skin; short limbs; dislocation of the hips and elbows; seizures; and intellectual disability. It is caused by genetic changes in the RNU4ATAC gene and is inherited in an autosomal recessive manner.
What are the alternative names for Microcephalic Osteodysplastic Primordial Dwarfism Type 1 (MOPD1)?
  • Microcephalic osteodysplastic primordial dwarfism type 1
  • Brachymelic primordial dwarfism
  • Cephaloskeletal dysplasia
  • Low-birth-weight dwarfism with skeletal dysplasia
  • MOPD 1
  • Microcephalic osteodysplastic primordial dwarfism types 1 and 3
  • Osteodysplastic primordial dwarfism type I
  • Primordial microcephalic dwarfism, Crachami type
  • Taybi-Linder syndrome
Who are the top Microcephalic Osteodysplastic Primordial Dwarfism Type 1 (MOPD1) Local Doctors?
Medical Genetics
Medical Genetics
1600 Sw Archer Rd, 
Gainesville, FL 
 (202.3 mi)
Languages Spoken:
English
Accepting New Patients

Daniel Driscoll is a Medical Genetics provider in Gainesville, Florida. Dr. Driscoll and is rated as a Distinguished provider by MediFind in the treatment of Microcephalic Osteodysplastic Primordial Dwarfism Type 1 (MOPD1). His top areas of expertise are Prader-Willi Syndrome, SHORT Syndrome, Aarskog Syndrome, and Camptodactyly Syndrome Guadalajara Type 2. Dr. Driscoll is currently accepting new patients.

Pediatric Endocrinology | Pediatrics | Endocrinology
Pediatric Endocrinology | Pediatrics | Endocrinology

Florida Clinical Practice Association Inc

2001 Sw 13th St, 
Gainesville, FL 
 (202.6 mi)
Languages Spoken:
English
Accepting New Patients

Jennifer Miller is a Pediatric Endocrinologist and a Pediatrics provider in Gainesville, Florida. Dr. Miller and is rated as a Distinguished provider by MediFind in the treatment of Microcephalic Osteodysplastic Primordial Dwarfism Type 1 (MOPD1). Her top areas of expertise are Prader-Willi Syndrome, Kenny-Caffey Syndrome Type 2, Craniofrontonasal Dysplasia, and Cockayne Syndrome. Dr. Miller is currently accepting new patients.

 
 
 
 
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Family Medicine
Family Medicine
3951 Nw 48th Ter, Suite 101, 
Gainesville, FL 
 (198.5 mi)
Languages Spoken:
English

Miriam Cope is a Family Medicine provider in Gainesville, Florida. Dr. Cope and is rated as an Experienced provider by MediFind in the treatment of Microcephalic Osteodysplastic Primordial Dwarfism Type 1 (MOPD1). Her top areas of expertise are Campomelic Dysplasia, Mulibrey Nanism, Camptodactyly Syndrome Guadalajara Type 1, and Osteoglophonic Dysplasia.

What are the latest Microcephalic Osteodysplastic Primordial Dwarfism Type 1 (MOPD1) Clinical Trials?
Study of the Consequences of Mutations of the RNU4ATAC and RTTN Genes by Transcriptomic, Biochemical and Cellular Approaches in Order to Determine the Pathophysiology of Their Associated Syndromes: Microcephalic Osteodysplastic Primordial Dwarfism Type I/III, Roifman Syndrome and Lowry-Wood Syndrome

Summary: In the human genome, about 750 genes contain one intron excised by the minor spliceosome. These genes are named U12 genes, and these introns, minor or U12 introns. The minor spliceosome comprises its own set of snRNAs, among which U4atac. Its non-coding gene, RNU4ATAC, has been found mutated in Taybi-Linder (TALS), Roifman (RFMN) and Lowry-Wood syndromes (LWS). These rare developmental disorders a...

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Primordial Registry at Nemours/A. I. duPont Hospital for Children

Summary: The goal of this registry is to collect information on individuals with forms of microcephalic primordial dwarfism. The study team hopes to learn more about these conditions and improve the care of people with it by establishing this registry.

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center