Learn About Multiple Endocrine Neoplasia
Multiple endocrine neoplasia is a group of disorders that affect the body's network of hormone-producing glands called the endocrine system. Hormones are chemical messengers that travel through the bloodstream and regulate the function of cells and tissues throughout the body. Multiple endocrine neoplasia typically involves tumors (neoplasia) in at least two endocrine glands; tumors can also develop in other organs and tissues. These growths can be noncancerous (benign) or cancerous (malignant). If the tumors become cancerous, the condition can be life-threatening.
Mutations in the MEN1, RET, and CDKN1B genes can cause multiple endocrine neoplasia.
Multiple endocrine neoplasia type 1 affects about 1 in 30,000 people; multiple endocrine neoplasia type 2 affects an estimated 1 in 35,000 people. Among the subtypes of type 2, type 2A is the most common form, followed by FMTC. Type 2B is relatively uncommon, accounting for about 5 percent of all cases of type 2. The prevalence of multiple endocrine neoplasia type 4 is unknown, although the condition appears to be rare.
Multiple endocrine neoplasia type 1 usually has an autosomal dominant pattern of inheritance. People with this condition are born with one mutated copy of the MEN1 gene in each cell. In most cases, the altered gene is inherited from an affected parent. The remaining cases are a result of new mutations in the MEN1 gene and occur in people with no history of the disorder in their family.
University Of Alabama Health Services Foundation, PC
Brenessa Lindeman is a Surgical Oncologist and an Endocrinologist in Birmingham, Alabama. Dr. Lindeman and is rated as an Experienced provider by MediFind in the treatment of Multiple Endocrine Neoplasia. Her top areas of expertise are Hyperparathyroidism, Parathyroid Hyperplasia, Milk-Alkali Syndrome, Parathyroidectomy, and Thyroidectomy. Dr. Lindeman is currently accepting new patients.
Sacred Heart Health System Inc
David Mann is a Hematologist Oncology specialist and a Hematologist in Andalusia, Alabama. Dr. Mann and is rated as an Advanced provider by MediFind in the treatment of Multiple Endocrine Neoplasia. His top areas of expertise are Colorectal Cancer, Familial Colorectal Cancer, Lung Cancer, and Pleuropulmonary Blastoma. Dr. Mann is currently accepting new patients.
University Of Alabama Health Services Foundation, PC
Sushanth Reddy is a General Surgeon in Birmingham, Alabama. Dr. Reddy and is rated as an Experienced provider by MediFind in the treatment of Multiple Endocrine Neoplasia. His top areas of expertise are Pancreatic Cancer, Neuroendocrine Tumor, Familial Pancreatic Cancer, Pancreatectomy, and Pancreaticoduodenectomy. Dr. Reddy is currently accepting new patients.
Summary: Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant disease with a high degree of penetrance (\>80% of patients). It is caused by the presence of the MEN1 mutation located on chromosome 11q13. The prevalence of this mutation is estimated at approximately 1/30,000. This hereditary syndrome is characterized by the presence of tumours of the endocrine system (adenoma of the parathyroi...
Background: - Medullary thyroid cancer (MTC) is a rare cancer of the thyroid gland. In children and adults, it is often part of a condition called Multiple Endocrine Neoplasia 2 (MEN2). MEN2 is usually caused by a genetic mutation, and it can cause a number of problems in addition to MTC. These problems include adrenal gland tumors, hormone changes, and problems with the bones and other organs. Not much is kn...
Published Date: March 01, 2017
Published By: National Institutes of Health