Oral Submucous Fibrosis Overview

Save information for later
Sign Up

Learn About Oral Submucous Fibrosis

What is the definition of Oral Submucous Fibrosis?
Oral submucous fibrosis (OSMF) is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in India and Southeast Asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro-pharynx (leading to trismus and a progressive reduction in mouth opening) and an increased risk of developing oral squamous cell cancer (3-19%). It is usually associated with the chewing of the areca nut (an ingredient in betel quid) but the exact etiology is unknown and there is currently no effective treatment.
What are the alternative names for Oral Submucous Fibrosis?
  • Oral submucous fibrosis
  • OSMF
Who are the top Oral Submucous Fibrosis Local Doctors?
Elite in Oral Submucous Fibrosis
Wanninayake M. Tilakaratne
Elite in Oral Submucous Fibrosis
Wanninayake M. Tilakaratne
Kuala Lumpur, MY 

Wanninayake Tilakaratne practices in Kuala Lumpur, Malaysia. Tilakaratne is rated as an Elite expert by MediFind in the treatment of Oral Submucous Fibrosis. Their top areas of expertise are Oral Submucous Fibrosis, Oral Cancer, Oral Squamous Cell Carcinoma, and Leukoplakia.

Elite in Oral Submucous Fibrosis
Saman P. Warnakulasuriya
Elite in Oral Submucous Fibrosis
Saman P. Warnakulasuriya
Denmark Hill Campus, Caldecot Road, 
London, ENG, GB 

Saman Warnakulasuriya practices in London, United Kingdom. Warnakulasuriya is rated as an Elite expert by MediFind in the treatment of Oral Submucous Fibrosis. Their top areas of expertise are Leukoplakia, Oral Submucous Fibrosis, Erythroplakia, Lichen Planus, and Thymectomy.

 
 
 
 
Learn about our expert tiers
Learn More
Elite in Oral Submucous Fibrosis
Sachin C. Sarode
Elite in Oral Submucous Fibrosis
Sachin C. Sarode

Dr. D.Y. Patil Dental College And Hospital

Pimpri, MH, IN 

Sachin Sarode practices in Pimpri, India. Mr. Sarode is rated as an Elite expert by MediFind in the treatment of Oral Submucous Fibrosis. His top areas of expertise are Oral Squamous Cell Carcinoma, Oral Submucous Fibrosis, Oral Cancer, and Lichen Planus.

View All Doctors
What are the latest Oral Submucous Fibrosis Clinical Trials?
Exploring the Fibrosis-Modulating Potential of Metformin and Pirfenidone in Oral Submucous Fibrosis: Molecular Mechanisms to Clinical Applications
Exploring the Fibrosis-Modulating Potential of Metformin and Pirfenidone in Oral Submucous Fibrosis: Molecular Mechanisms to Clinical Applications
Enrollment Status: Recruiting
Publish Date: December 02, 2025
Intervention Type: Drug
Study Phase: Phase 1/Phase 2

Summary: The goal of this clinical trial is to learn if metformin and antifibrotic drugs (pirfenidone) can modulate fibrosis and improve treatment outcomes in patients with oral submucous fibrosis (OSF). The study also aims to investigate the molecular mechanisms underlying their effects on exosome secretion and protein expression. The main questions it aims to answer are: Do metformin and antifibrotic dru...

Match to trials
Find the right clinical trials for you in under a minute
Get started
Saliva as Early Detection Tool for Oral Cancer
Saliva as Early Detection Tool for Oral Cancer
Enrollment Status: Recruiting
Publish Date: August 14, 2025
Intervention Type: Diagnostic test

Summary: Oral cancer is the top cancer in Pakistan, accounting for 27%, and it has a high mortality rate due to late-stage diagnosis. It primarily affects the lips, tongue, cheeks, and floor of the mouth. Major risk factor for oral cancer development is pan supari chhaliya chewing. Patients often develop a pre-malignant condition, oral submucous fibrosis, resulting in limited mouth opening. Thus, patients ...

View All Clinical Trials
Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center