Palmoplantar Keratoderma Overview

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Learn About Palmoplantar Keratoderma

What is the definition of Palmoplantar Keratoderma?
Palmoplantar keratoderma (PPK) is a group of skin conditions characterized by thickening of the skin on the palms of the hands and soles of the feet. PPK can also be a feature of various underlying syndromes. In rare forms of PPK, organs other than the skin may also be affected. PPK can be either acquired during the lifetime (more commonly) or inherited. Acquired PPKs may arise due to changes in a person's health or environment. Inherited PPKs are caused by genetic changes that result in abnormalities of keratin, a skin protein. Depending on the genetic cause, inheritance can be autosomal dominant or autosomal recessive.
What are the alternative names for Palmoplantar Keratoderma?
  • Palmoplantar keratoderma
  • Keratoderma, Palmoplantar
Who are the top Palmoplantar Keratoderma Local Doctors?

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What are the latest Palmoplantar Keratoderma Clinical Trials?
National Cohort for Evaluation of the Burden of Rare Skin Diseases
National Cohort for Evaluation of the Burden of Rare Skin Diseases
Enrollment Status: Recruiting
Publish Date: February 04, 2025

Summary: The goal of this observational study is to conduct a prospective assessment of the individual Burden of 9 rare skin diseases to assess disability in the broadest sense of the term (psychological, social, economic and physical) for patients and/or families. Two types of indicators will be used to reach this objective : 1. an individual burden score calculated based on a burden questionnaire created...

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An Open-label, Phase II Study to Evaluate the Clinical Efficacy and Safety of Tapinarof for Adult Patients With Palmoplantar Keratoderma
An Open-label, Phase II Study to Evaluate the Clinical Efficacy and Safety of Tapinarof for Adult Patients With Palmoplantar Keratoderma
Enrollment Status: Recruiting
Publish Date: December 20, 2024
Intervention Type: Drug
Study Phase: Phase 2

Summary: The purpose of this study is to assess adults with palmoplantar keratoderma (thickening skin layer on palms and soles) who are treated with the study drug, tapinarof. This is a naturally occuring compound used for the treatment of psoriasis. This study is being done to find out how well and safe this drug is for stopping or treating keratoderma. This study aims to investigate the positive impacts ...

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center