Primary Lateral Sclerosis Overview

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Learn About Primary Lateral Sclerosis

What is the definition of Primary Lateral Sclerosis?
Primary lateral sclerosis (PLS) is a rare neuromuscular disease that affects the nerve cells that control the voluntary muscles. Problems in the legs (such as weakness, stiffness, spasticity, and balance problems) are often observed first, but hand clumsiness and changes in speech can be early symptoms, as well. The underlying cause of adult PLS is currently unknown. In most cases, it occurs sporadically in people with no family history of the condition. A subtype of PLS, called juvenile PLS, is caused by changes in the ALS2 gene and is inherited in an autosomal recessive manner.
What are the alternative names for Primary Lateral Sclerosis?
  • Primary lateral sclerosis
  • Adult-onset PLS
  • Adult-onset primary lateral sclerosis
Who are the top Primary Lateral Sclerosis Local Doctors?
Experienced in Primary Lateral Sclerosis
Dr. Marlena M. Szewczyk
Internal Medicine
Experienced in Primary Lateral Sclerosis
Dr. Marlena M. Szewczyk
Internal Medicine

Intermountain Medical Group Denver, LLC

2600 Campus Dr, Suite A, 
Lafayette, CO 
 (4.7 mi)
303-673-1900
Languages Spoken:
English
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Accepting New Patients

Marlena Szewczyk is an Internal Medicine provider in Lafayette, Colorado. Dr. Szewczyk and is rated as an Experienced provider by MediFind in the treatment of Primary Lateral Sclerosis. Her top areas of expertise are Swallowing Difficulty, Primary Lateral Sclerosis, Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), and Restless Legs Syndrome. Dr. Szewczyk is currently accepting new patients.

Distinguished in Primary Lateral Sclerosis
Dr. Julie A. Parsons
Pediatric Neurology | Neurology
Distinguished in Primary Lateral Sclerosis
Dr. Julie A. Parsons
Pediatric Neurology | Neurology
13123 E 16th Ave, 
Aurora, CO 
 (18.2 mi)
720-777-1234
Languages Spoken:
English
See accepted insurances
Accepting New Patients

Julie Parsons is a Pediatric Neurologist and a Neurologist in Aurora, Colorado. Dr. Parsons and is rated as a Distinguished provider by MediFind in the treatment of Primary Lateral Sclerosis. Her top areas of expertise are Spinal Muscular Atrophy (SMA), Primary Lateral Sclerosis, Spinal Muscular Atrophy Type 2, and Spinal Muscular Atrophy Type 3. Dr. Parsons is currently accepting new patients.

 
 
 
 
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Advanced in Primary Lateral Sclerosis
Dr. Dianna Quan
Neurology
Advanced in Primary Lateral Sclerosis
Dr. Dianna Quan
Neurology

University Physicians Incorporated

12605 E 16th Ave, Uchealth Anschutz Medical Campus, 
Aurora, CO 
 (17.9 mi)
720-848-0000
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Dianna Quan is a Neurologist in Aurora, Colorado. Dr. Quan and is rated as an Advanced provider by MediFind in the treatment of Primary Lateral Sclerosis. Her top areas of expertise are Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), Spinal Muscular Atrophy (SMA), Spinal and Bulbar Muscular Atrophy, and Spinal Muscular Atrophy Type 3. Dr. Quan is currently accepting new patients.

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What are the latest Primary Lateral Sclerosis Clinical Trials?
First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of Intrathecally Administered ALN-SOD in Participants With Amyotrophic Lateral Sclerosis and SOD1 Mutations
First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of Intrathecally Administered ALN-SOD in Participants With Amyotrophic Lateral Sclerosis and SOD1 Mutations
Enrollment Status: Recruiting
Publish Date: February 26, 2025
Intervention Type: Other, Drug
Study Phase: Phase 1

Summary: This study is researching an experimental drug called ALN-SOD (called study drug). This study is focused on people with amyotrophic lateral sclerosis (ALS) caused by a change in a gene called the superoxide dismutase-1 (SOD1) gene. This type of ALS is known as SOD1-ALS. This is the first time that ALN-SOD will be given to people. The aim of the study is to see how safe and tolerable the study drug...

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The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study
The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study
Enrollment Status: Recruiting
Publish Date: February 26, 2025

Summary: Pre-fALS is a prospective natural history and biomarker study of people not yet affected with ALS, but who are at genetic risk for developing ALS. The investigators aim to recruit unaffected (healthy) people from familial ALS (fALS) pedigrees in which a known genetic mutation associated with ALS has been identified; for this study, a fALS pedigree is one with two biologically related individuals w...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center