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Learn About Primary Localized Cutaneous Amyloidosis

What is the definition of Primary Localized Cutaneous Amyloidosis?

Primary localized cutaneous amyloidosis (PLCA) is a condition in which clumps of abnormal proteins called amyloids build up in the skin, specifically in the wave-like projections (dermal papillae) between the top two layers of skin (the dermis and the epidermis). The primary feature of PLCA is patches of skin with abnormal texture or color. The appearance of these patches defines three forms of the condition: lichen amyloidosis, macular amyloidosis, and nodular amyloidosis.

What are the causes of Primary Localized Cutaneous Amyloidosis?

PLCA can be caused by mutations in the OSMR or IL31RA gene. When caused by an OSMR gene mutation, the condition is classified as type 1, while an IL31RA gene mutation causes type 2. Mutations in either gene are likely involved in lichen and macular amyloidosis, which are thought to be related conditions that arise through similar disease mechanisms. The genetic basis of nodular amyloidosis is unknown.

How prevalent is Primary Localized Cutaneous Amyloidosis?

PLCA occurs worldwide, most commonly in Southeast Asia and South America. The prevalence of the condition is unknown.

Is Primary Localized Cutaneous Amyloidosis an inherited disorder?

In most cases, PLCA is not inherited and occurs in people with no history of the condition in their family.

Who are the top Primary Localized Cutaneous Amyloidosis Local Doctors?
Neurology | Psychiatry
Neurology | Psychiatry

Mainehealth

22 Bramhall St, 
Portland, ME 
 51.7 mi
Accepting New Patients
Offers Telehealth

Eric Dinnerstein is a Neurologist and a Psychiatrist in Portland, Maine. Dr. Dinnerstein and is rated as an Advanced provider by MediFind in the treatment of Primary Localized Cutaneous Amyloidosis. His top areas of expertise are Cerebellar Degeneration, Parkinson's Disease, Alzheimer's Disease, and Memory Loss. Dr. Dinnerstein is currently accepting new patients.

Mainehealth

4 Glen Cove Dr, 
Rockport, ME 
 36.2 mi
Accepting New Patients
Offers Telehealth

Robert Stein is a Neurologist in Rockport, Maine. Dr. Stein and is rated as an Experienced provider by MediFind in the treatment of Primary Localized Cutaneous Amyloidosis. His top areas of expertise are Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE), Stroke, Myasthenia Gravis, and Partial Seizure. Dr. Stein is currently accepting new patients in some locations.

 
 
 
 
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Hematology Oncology | Oncology | Hematology
Hematology Oncology | Oncology | Hematology
33 Whiting Hill Rd, Suite 21, 
Brewer, ME 
 60.7 mi
Accepting New Patients
Offers Telehealth

Thomas Openshaw is a Hematologist Oncology specialist and an Oncologist in Brewer, Maine. Dr. Openshaw and is rated as an Experienced provider by MediFind in the treatment of Primary Localized Cutaneous Amyloidosis. His top areas of expertise are Primary Amyloidosis, Renal Cell Carcinoma (RCC), Breast Cancer, Polycythemia Vera, and Bone Marrow Aspiration. Dr. Openshaw is currently accepting new patients.

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Who are the sources who wrote this article ?

Published Date: March 01, 2017
Published By: National Institutes of Health