Primary Lymphoma of the Brain Overview
Learn About Primary Lymphoma of the Brain
View Main Condition: Brain Tumor
Primary lymphoma of the brain is cancer of white blood cells that starts in the brain.
Brain lymphoma; Cerebral lymphoma; Primary lymphoma of the central nervous system; PCNSL; Lymphoma - B-cell lymphoma, brain
The cause of primary brain lymphoma is not known.
People with a weakened immune system are at high risk for primary lymphoma of the brain. Common causes of a weakened immune system include HIV/AIDS and having had an organ transplant (especially heart transplant).
Primary lymphoma of the brain may be linked to Epstein-Barr virus (EBV), especially in people with HIV/AIDS. EBV is the virus that causes mononucleosis.
Primary brain lymphoma is more common in people ages 45 to 70. The rate of primary brain lymphoma is rising. Almost 1,500 new patients are diagnosed with primary brain lymphoma every year in the United States.
Symptoms of primary brain lymphoma may include any of the following:
- Changes in speech or vision
- Confusion or hallucinations
- Seizures
- Headaches, nausea, or vomiting
- Leaning to one side when walking
- Weakness in hands or loss of coordination
- Numbness to hot, cold, and pain
- Personality changes
- Weight loss
The main treatment is with chemotherapy and certain monoclonal antibodies, which are a type of lab-made protein to treat many diseases, including cancer.
Younger people may receive high-dose chemotherapy, possibly followed by an autologous stem cell transplant.
Radiation therapy of the whole brain may be done after chemotherapy, but is often avoided due to potential neurologic complications.
Boosting the immune system, such as in those with HIV/AIDS or a history of organ transplant, may also be tried.
Texas Tech Physicians Of El Paso
Javier Corral is a Hematologist Oncology specialist and a Hematologist in El Paso, Texas. Dr. Corral and is rated as an Experienced provider by MediFind in the treatment of Primary Lymphoma of the Brain. His top areas of expertise are Colorectal Cancer, Lynch Syndrome, Gastric Lymphoma, and Familial Colorectal Cancer. Dr. Corral is currently accepting new patients.
Texas Tech Physicians Of El Paso
Sumit Gaur is a Hematologist Oncology specialist and a Hematologist in El Paso, Texas. Dr. Gaur and is rated as an Experienced provider by MediFind in the treatment of Primary Lymphoma of the Brain. His top areas of expertise are Breast Cancer, Paget Disease of the Breast, Diencephalic Syndrome, Neural Crest Tumor, and Gallbladder Removal. Dr. Gaur is currently accepting new patients.
Texas Oncology PA
Habte Yimer is a Hematologist Oncology specialist and an Oncologist in El Paso, Texas. Dr. Yimer and is rated as an Advanced provider by MediFind in the treatment of Primary Lymphoma of the Brain. His top areas of expertise are Lung Cancer, Pleuropulmonary Blastoma, Chronic Lymphocytic Leukemia (CLL), and Paget Disease of the Breast. Dr. Yimer is currently accepting new patients.
Without treatment, people with primary brain lymphoma survive for less than 6 months. When treated with chemotherapy, half of the patients will be in remission 10 years after being diagnosed. Survival may improve with autologous stem cell transplant.
Possible complications include:
- Chemotherapy side effects, including low blood counts
- Radiation side effects, including confusion, headaches, nervous system (neurologic) problems, and tissue death
- Return (recurrence) of the lymphoma
Summary: Primary central nervous system (CNS) lymphomas represent 5% of primary brain tumors. More than 90% of them are diffuse large B-cell lymphomas. \[18F\]-Fluorodeoxyglucose positron emission tomography (PET-\[18F\]-FDG) is the gold standard for imaging systemic lymphomas, but its application in primary CNS lymphoma is compromised by the limited specificity of brain fixations and the high uptake of \[...
Published Date: March 31, 2024
Published By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
National Cancer Institute website. Primary CNS lymphoma treatment (PDQ) - health professional version. www.cancer.gov/types/lymphoma/hp/primary-cns-lymphoma-treatment-pdq. Updated December 2, 2022. Accessed May 13, 2024.
National Comprehensive Cancer Network website. NCCN clinical practice guidelines in oncology (NCCN guidelines): central nervous system cancers. Version 1.2023. www.nccn.org/professionals/physician_gls/pdf/cns.pdf. Updated May 31, 2024. Accessed June 18, 2024.
Roque A, Hochberg FH, Baehring JM. Primary nervous system tumors in adults. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 74.