Protein C Deficiency Overview
Learn About Protein C Deficiency
Protein C deficiency is a disorder that increases the risk of developing abnormal blood clots; the condition can be mild or severe.
Protein C deficiency is caused by mutations in the PROC gene. This gene provides instructions for making protein C, which is found in the bloodstream and is important for controlling blood clotting. Protein C blocks the activity of (inactivates) certain proteins that promote blood clotting.
Mild protein C deficiency affects approximately 1 in 500 individuals. Severe protein C deficiency is rare and occurs in an estimated 1 in 4 million newborns.
Protein C deficiency is inherited in an autosomal dominant pattern, which means one altered copy of the PROC gene in each cell is sufficient to cause mild protein C deficiency. Individuals who inherit two altered copies of this gene in each cell have severe protein C deficiency.
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Nancy Dawson is an Oncologist and a Hematologist Oncology provider in Washington, Washington, D.c.. Dr. Dawson has been practicing medicine for over 46 years and is rated as an Experienced provider by MediFind in the treatment of Protein C Deficiency. Her top areas of expertise are Prostate Cancer, Familial Prostate Cancer, Renal Cell Carcinoma (RCC), Chromophobe Renal Cell Carcinoma, and Prostatectomy. Dr. Dawson is currently accepting new patients.
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Craig Kessler is a Hematologist Oncology specialist and a Hematologist in Washington, Washington, D.c.. Dr. Kessler and is rated as a Distinguished provider by MediFind in the treatment of Protein C Deficiency. His top areas of expertise are Blood Clots, Hemophilia A, Acquired Hemophilia, Bone Marrow Aspiration, and Splenectomy. Dr. Kessler is currently accepting new patients.
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Catherine Broome is a Hematologist Oncology specialist and a Hematologist in Washington, Washington, D.c.. Dr. Broome has been practicing medicine for over 40 years and is rated as an Experienced provider by MediFind in the treatment of Protein C Deficiency. Her top areas of expertise are Autoimmune Hemolytic Anemia, Thrombocytopenia, Chronic B-Cell Leukemia (CBCL), Bone Marrow Aspiration, and Splenectomy. Dr. Broome is currently accepting new patients.
Summary: This study is conducted in Japan of Freeze-dried Human Protein C Concentrate (TAK-662) used to treat participants with congenital protein C deficiency. The main aim of the study is to evaluate for adverse events and effectiveness of congenital protein C deficiency (TAK-662). During the study, participants with congenital protein C deficiency will be administered with TAK-662 intravenous injection ...
Published Date: May 01, 2013
Published By: National Institutes of Health