Sarcoidosis Overview
Learn About Sarcoidosis
Sarcoidosis is a disease in which inflammation occurs in the lymph nodes, lungs, liver, eyes, skin, and/or other tissues.
The exact cause of sarcoidosis is unknown. What is known is that when a person has the disease, tiny clumps of abnormal tissue (granulomas) form in certain organs of the body. Granulomas are clusters of immune cells.
The disease can affect almost any organ. It most commonly affects the lungs.
Health experts think that having certain genes makes it more likely for a person to develop sarcoidosis. Things that may trigger the disease include infections with bacteria or viruses. Contact with dust or chemicals may also be triggers.
The disease is more common in African Americans and White people of Scandinavian heritage. More women than men have the disease.
The disease often begins between ages 20 and 40. Sarcoidosis is rare in young children.
A person with a close blood relative who has sarcoidosis is nearly 5 times as likely to develop the condition.
There may be no symptoms. When symptoms do occur, they can involve almost any body part or organ system.
Almost all people affected by sarcoidosis have lung or chest symptoms:
- Chest pain (most often behind the breast bone)
- Dry cough
- Shortness of breath
- Coughing up blood (rare, but serious)
Symptoms of general discomfort may include:
- Fatigue
- Fever
- Joint ache or pain (arthralgia)
- Weight loss
Skin symptoms may include:
- Hair loss
- Raised, red, firm skin sores (erythema nodosum), almost always on the front part of the lower legs
- Rash
- Scars that become raised or inflamed
Nervous system symptoms may include:
- Headache
- Seizures
- Weakness on one side of the face
Eye symptoms may include:
- Burning, itching, discharge from the eye
- Dry eyes
- Pain
- Vision loss
Other symptoms of this disease may include:
- Dry mouth
- Fainting spells, if the heart is involved
- Nosebleed
- Swelling in the upper part of the abdomen
- Liver disease
- Swelling of the legs if heart and lungs are involved
- Abnormal heart rhythm if the heart is involved
Sarcoidosis symptoms will often get better without treatment, especially if there are only small lung abnormalities.
If the eyes, heart, nervous system, or lungs are affected, corticosteroids are usually prescribed. This medicine may need to be taken for 1 to 2 years.
Medicines that suppress the immune system are sometimes also needed.
In rare cases, people with very severe heart or lung damage (end-stage disease) may need an organ transplant.
With sarcoidosis that affects the heart, an implantable cardioverter-defibrillator (ICD) may be needed to treat heart rhythm problems.
Sarsam Cardiology A Professional Corporation
Sinan Sarsam is a Cardiologist and an Interventional Cardiologist in Temecula, California. Dr. Sarsam and is rated as an Experienced provider by MediFind in the treatment of Sarcoidosis. His top areas of expertise are Apoplexy, Heart Attack, Ventricular Fibrillation, and Arterial Embolism.
Timothy Killeen is a Pulmonary Medicine provider in Temecula, California. Dr. Killeen and is rated as an Experienced provider by MediFind in the treatment of Sarcoidosis. His top areas of expertise are Lung Metastases, Lung Cancer, Pneumonia, Advanced Bronchoscopy, and Gastrostomy.
Jason Black is an Internal Medicine provider in Murrieta, California. Dr. Black and is rated as an Experienced provider by MediFind in the treatment of Sarcoidosis. His top areas of expertise are Cerebral Palsy, Spasticity, Athetosis, and Ochoa Syndrome.
Many people with sarcoidosis are not seriously ill, and get better without treatment. Up to half of all people with the disease get better in 3 years without treatment. People whose lungs are affected may develop lung damage.
Overall the death rate from sarcoidosis is less than 5%. Causes of death include:
- Bleeding from the lung tissue
- Heart damage, leading to heart failure and abnormal heart rhythms
- Lung scarring (pulmonary fibrosis)
Sarcoidosis may lead to these health problems:
- Fungal lung infections (aspergillosis)
- Glaucoma and blindness from uveitis (rare)
- Kidney stones from high calcium levels in blood or urine
- Osteoporosis and other complications of taking corticosteroids for long periods of time
- High blood pressure in the arteries of the lungs (pulmonary hypertension)
Contact your provider promptly if you have:
- Difficulty breathing
- Irregular heartbeat
- Vision changes
- Other symptoms of this disorder
Summary: The primary objective of this study is to evaluate the effect of rilonacept, added to standard therapy and compared with standard therapy alone, on improvement in myocardial inflammation in subjects with cardiac sarcoidosis after 24 weeks of therapy.
Summary: This is a Phase 2, randomized, double-blind, placebo-controlled, adaptive, multicenter study to evaluate the efficacy, safety, tolerability, Pharmacodynamics (PD), and Pharmacokinetics (PK) of OATD-01 in the treatment of subjects with active pulmonary sarcoidosis.
Published Date: May 03, 2023
Published By: Denis Hadjiliadis, MD, MHS, Paul F. Harron, Jr. Professor of Medicine, Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania,Philadelphia, PA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Iannuzzi MC. Sarcoidosis. Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 89.
Judson MA, Koth LL, Baughman RP. Sarcoidosis. In: Broaddus VC, Ernst JD, King TE, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. 7th ed. Philadelphia, PA: Elsevier; 2022:chap 93.
Soto-Gomez N, Peters JI, Nambiar AM. Diagnosis and management of sarcoidosis. Am Fam Physician. 2016;93(10):840-848. PMID: 27175719 pubmed.ncbi.nlm.nih.gov/27175719/.