Severe Combined Immunodeficiency (SCID) Overview

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Learn About Severe Combined Immunodeficiency (SCID)

What is the definition of Severe Combined Immunodeficiency (SCID)?
Severe combined immunodeficiencies (SCID) are inherited immune system disorders characterized by abnormalities with responses of both T cells and B cells (specific types of white blood cells needed for immune system function). Common signs and symptoms include an increased susceptibility to infections including ear infections; pneumonia or bronchitis; oral thrush; and diarrhea. Due to recurrent infections, children with SCID do not grow and gain weight as expected (failure to thrive). SCID may be caused by genetic changes in any of several genes and can be inherited in an X-linked recessive (most commonly) or autosomal recessive manner. The most common type of SCID is called X-linked Severe combined immunodeficiency (XSCID). Another form of SCID is caused by a deficiency of the enzyme adenosine deaminase (ADA).
What are the alternative names for Severe Combined Immunodeficiency (SCID)?
  • Severe combined immunodeficiency
  • SCID
Who are the top Severe Combined Immunodeficiency (SCID) Local Doctors?
Elite in Severe Combined Immunodeficiency (SCID)
Dr. Hans-peter P. Kiem
Hematology Oncology | Oncology
Elite in Severe Combined Immunodeficiency (SCID)
Dr. Hans-peter P. Kiem
Hematology Oncology | Oncology
University Of Washington Medical Ctr, 1959 Ne Pacific St, 
Seattle, WA 
 (5.6 mi)
206-288-1000
Languages Spoken:
English, German, Mandarin, Spanish, Swedish
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Hans-peter Kiem is a Hematologist Oncology specialist and an Oncologist in Seattle, Washington. Dr. Kiem and is rated as an Elite provider by MediFind in the treatment of Severe Combined Immunodeficiency (SCID). His top areas of expertise are X-Linked Severe Combined Immunodeficiency, Congenital Aplastic Anemia, Fanconi Anemia, Severe Combined Immunodeficiency (SCID), and Bone Marrow Transplant. Dr. Kiem is currently accepting new patients.

Distinguished in Severe Combined Immunodeficiency (SCID)
Dr. Andrew M. Scharenberg
Pediatric Allergy and Immunology | Pediatrics
Distinguished in Severe Combined Immunodeficiency (SCID)
Dr. Andrew M. Scharenberg
Pediatric Allergy and Immunology | Pediatrics
4800 Sand Point Way Ne, 
Seattle, WA 
 (5.3 mi)
206-987-2000
Languages Spoken:
English
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Accepting New Patients
Offers Telehealth

Andrew Scharenberg is a Pediatric Allergy and Immunologist and a Pediatrics provider in Seattle, Washington. Dr. Scharenberg and is rated as a Distinguished provider by MediFind in the treatment of Severe Combined Immunodeficiency (SCID). His top areas of expertise are X-Linked Severe Combined Immunodeficiency, Severe Combined Immunodeficiency (SCID), Anemia, and Immunodeficiency with Hyper IgM Type 1. Dr. Scharenberg is currently accepting new patients.

 
 
 
 
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Distinguished in Severe Combined Immunodeficiency (SCID)
Dr. Lauri M. Burroughs
Pediatric Hematology Oncology | Hematology | Pediatrics
Distinguished in Severe Combined Immunodeficiency (SCID)
Dr. Lauri M. Burroughs
Pediatric Hematology Oncology | Hematology | Pediatrics
4800 Sand Point Way Ne, 
Seattle, WA 
 (5.3 mi)
206-987-2106
Languages Spoken:
English, Hungarian, Japanese, Korean, Spanish, Vietnamese
See accepted insurances
Accepting New Patients
Offers Telehealth

Lauri Burroughs is a Pediatric Hematologist Oncology specialist and a Hematologist in Seattle, Washington. Dr. Burroughs and is rated as a Distinguished provider by MediFind in the treatment of Severe Combined Immunodeficiency (SCID). Her top areas of expertise are Severe Combined Immunodeficiency (SCID), Wiskott-Aldrich Syndrome, Aplastic Anemia, Primary Immunodeficiency (PID), and Bone Marrow Transplant. Dr. Burroughs is currently accepting new patients.

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What are the latest Severe Combined Immunodeficiency (SCID) Clinical Trials?
Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age With X-Linked Severe Combined Immunodeficiency
Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age With X-Linked Severe Combined Immunodeficiency
Who is this study for: Child to adult male patients with Severe Combined Immune Deficiency
Enrollment Status: Recruiting
Publish Date: February 24, 2025
Intervention Type: Biological, Drug
Study Drugs: Palifermin, Busulfan, Autologous CD34-Positive VSV-G Pseudotyped CL20-4i-EF1a-hyc-OPT Vector Hematopoietic Stem Cell Infusion
Study Phase: Phase 1/Phase 2

Summary: This is a Phase I/II non-randomized clinical trial of ex vivo hematopoietic stem cell (HSC) gene transfer treatment for X-linked severe combined immunodeficiency (XSCID, also known as SCID-X1) using a self-inactivating lentiviral vector incorporating additional features to improve safety and performance. The study will treat 35 patients with XSCID who are between 2 and 50 years of age and who have...

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Universal Genomic Newborn Screening in the Wallonia-Brussels Federation: Baby Detect
Universal Genomic Newborn Screening in the Wallonia-Brussels Federation: Baby Detect
Enrollment Status: Recruiting
Publish Date: February 12, 2025

Summary: Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions. With a simple blood test, rare genetic conditions can be easily detected, and the early start of transformative treatment will help avoid severe disabilities and increase the quality of life. Baby Detect Project is an innovative NBS program using a pane...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center