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Learn About Stevens-Johnson Syndrome

What is the definition of Stevens-Johnson Syndrome?

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a severe skin reaction most often triggered by particular medications. Although Stevens-Johnson syndrome and toxic epidermal necrolysis were once thought to be separate conditions, they are now considered part of a continuum. Stevens-Johnson syndrome represents the less severe end of the disease spectrum, and toxic epidermal necrolysis represents the more severe end.

What are the causes of Stevens-Johnson Syndrome?

Several genetic changes have been found to increase the risk of SJS/TEN in response to triggering factors such as medications. Most of these changes occur in genes that are involved in the normal function of the immune system.

How prevalent is Stevens-Johnson Syndrome?

SJS/TEN is a rare disease, affecting 1 to 2 per million people each year. Stevens-Johnson syndrome (the less severe form of the condition) is more common than toxic epidermal necrolysis.

Is Stevens-Johnson Syndrome an inherited disorder?

SJS/TEN is not an inherited condition. However, the genetic changes that increase the risk of developing SJS/TEN can be passed from one generation to the next.

Who are the top Stevens-Johnson Syndrome Local Doctors?

Longwood Eye LLC

180 Daggett Dr, 
West Springfield, MA 
 2.8 mi

Vamsee Neerukonda is an Ophthalmologist in West Springfield, Massachusetts. Dr. Neerukonda has been practicing medicine for over 9 years and is rated as an Experienced provider by MediFind in the treatment of Stevens-Johnson Syndrome. His top areas of expertise are Pinguecula, Mucopolysaccharidosis Type 1 (MPS I, Hurler Syndrome), Uveitis, and Dacryoadenitis.

Ophthalmology
Ophthalmology

Yale University

40 Temple St, Suite 1a, 
New Haven, CT 
 57.8 mi

Yvonne Wang is an Ophthalmologist in New Haven, Connecticut. Dr. Wang and is rated as an Experienced provider by MediFind in the treatment of Stevens-Johnson Syndrome. Her top areas of expertise are Scalded Skin Syndrome, Erythema Multiforme, Stevens-Johnson Syndrome, Vitrectomy, and Corneal Transplant.

 
 
 
 
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University Of Connecticut Health Center

263 Farmington Ave, 
Farmington, CT 
 27.6 mi
Accepting New Patients

Jane Grant-Kels is a Dermatologist in Farmington, Connecticut. Dr. Grant-Kels and is rated as an Experienced provider by MediFind in the treatment of Stevens-Johnson Syndrome. Her top areas of expertise are Pompholyx Eczema, Familial Atypical Multiple Mole Melanoma Syndrome, Melanoma, and Basal Cell Skin Cancer. Dr. Grant-Kels is currently accepting new patients.

What are the latest Stevens-Johnson Syndrome Clinical Trials?
An Open-Label Pilot Study to Evaluate the Safety, Tolerability, and Efficacy of Tofacitinib in Patients With Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)

Summary: The goal of this study is to evaluate the effect of tofacitinib in patients with Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). The primary outcome of the study is the time to complete re-epithelialization. The secondary outcomes are to determine mortality, length of hospitalization, adverse events, the time to beginning of epithelization, the time to halting of progression o...

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Evaluating the Therapeutic Efficacy of Filgrastim in Severe Bullous Drug Eruptions (Lyell and Stevens-Johnson Syndromes)

Summary: Toxic epidermal necrolysis (TEN) including Stevens Johnson (SJS) and Lyell syndromes represent the most severe drug eruptions. It is an allergic disorder caused by cytotoxic T lymphocytes, specific of drugs, responsible for the destruction of keratinocytes by apoptosis. Regulatory T cell (CD25 high CD4+), normally responsible for controlling the activation of cytotoxic T lymphocytes, have altered ...

Who are the sources who wrote this article ?

Published Date: January 01, 2020
Published By: National Institutes of Health