Stevens-Johnson Syndrome Overview
Learn About Stevens-Johnson Syndrome
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a severe skin reaction most often triggered by particular medications. Although Stevens-Johnson syndrome and toxic epidermal necrolysis were once thought to be separate conditions, they are now considered part of a continuum. Stevens-Johnson syndrome represents the less severe end of the disease spectrum, and toxic epidermal necrolysis represents the more severe end.
Several genetic changes have been found to increase the risk of SJS/TEN in response to triggering factors such as medications. Most of these changes occur in genes that are involved in the normal function of the immune system.
SJS/TEN is a rare disease, affecting 1 to 2 per million people each year. Stevens-Johnson syndrome (the less severe form of the condition) is more common than toxic epidermal necrolysis.
SJS/TEN is not an inherited condition. However, the genetic changes that increase the risk of developing SJS/TEN can be passed from one generation to the next.
University Of Pittsburgh Physicians
Vishal Jhanji is an Ophthalmologist in Pittsburgh, Pennsylvania. Dr. Jhanji and is rated as an Experienced provider by MediFind in the treatment of Stevens-Johnson Syndrome. His top areas of expertise are Pterygium, Interstitial Keratitis, Keratoconus, Corneal Transplant, and Cataract Removal. Dr. Jhanji is currently accepting new patients.
University Of Pittsburgh Physicians
Alain Corcos is a General Surgeon and an Intensive Care Medicine provider in Pittsburgh, Pennsylvania. Dr. Corcos and is rated as an Experienced provider by MediFind in the treatment of Stevens-Johnson Syndrome. His top areas of expertise are Delirium, Chronic Subdural Hematoma, Subdural Hematoma, Gastrostomy, and Splenectomy.
University Of Pittsburgh Physicians
Jenny Ziembicki is a General Surgeon in Pittsburgh, Pennsylvania. Dr. Ziembicki and is rated as an Experienced provider by MediFind in the treatment of Stevens-Johnson Syndrome. Her top areas of expertise are Subdural Hematoma, Delirium, Chronic Subdural Hematoma, Stevens-Johnson Syndrome, and Gastrostomy.
Summary: The goal of this study is to evaluate the effect of tofacitinib in patients with Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). The primary outcome of the study is the time to complete re-epithelialization. The secondary outcomes are to determine mortality, length of hospitalization, adverse events, the time to beginning of epithelization, the time to halting of progression o...
Summary: Toxic epidermal necrolysis (TEN) including Stevens Johnson (SJS) and Lyell syndromes represent the most severe drug eruptions. It is an allergic disorder caused by cytotoxic T lymphocytes, specific of drugs, responsible for the destruction of keratinocytes by apoptosis. Regulatory T cell (CD25 high CD4+), normally responsible for controlling the activation of cytotoxic T lymphocytes, have altered ...
Published Date: January 01, 2020
Published By: National Institutes of Health