Systemic Capillary Leak Syndrome Overview

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Learn About Systemic Capillary Leak Syndrome

What is the definition of Systemic Capillary Leak Syndrome?
Systemic capillary leak syndrome (SCLS) causes fluid and proteins to leak out of tiny blood vessels (capillaries) into surrounding tissues. This may lead to very low blood pressure (hypotension), hypoalbuminemia, and thickened blood due to a decrease in plasma volume (hemoconcentration). Initial symptoms may include tiredness, nausea, abdominal pain, extreme thirst, and sudden increase in body weight. Complications can include general swelling, compartment syndrome, kidney failure, and stroke. SCLS occurs in episodes which vary in frequency, with some people having one episode in their lifetime, and others having several per year. The severity also varies, and the condition can be fatal. In many cases, the cause is not known (idiopathic SCLS). Diagnosis is based on the symptoms, clinical examination and other laboratory tests.
What are the alternative names for Systemic Capillary Leak Syndrome?
  • Systemic capillary leak syndrome
  • Capillary leak syndrome
  • Capillary leak syndrome with monoclonal gammopathy
  • Clarkson disease
  • Periodic systemic capillary leak syndrome
  • SCLS
Who are the top Systemic Capillary Leak Syndrome Local Doctors?
Dr. David Pomerantz
Dermatology
Dr. David Pomerantz
Dermatology

David S Pomerantz MD Inc

333 School St, Suite 112a, 
Pawtucket, RI 
 (3.5 mi)
401-728-6990
Languages Spoken:
English
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David Pomerantz is a Dermatologist in Pawtucket, Rhode Island. Dr. Pomerantz and is rated as an Experienced provider by MediFind in the treatment of Systemic Capillary Leak Syndrome. His top areas of expertise are Universal Acquired Melanosis, Liver Spots, Seborrheic Keratosis, and Warts.

Dr. Carolynn J. Nassar
Internal Medicine
Dr. Carolynn J. Nassar
Internal Medicine

Brown Medicine

375 Wampanoag Trl, 
Riverside, RI 
 (3.9 mi)
401-649-4010
Languages Spoken:
English
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Carolynn Nassar is an Internal Medicine provider in Riverside, Rhode Island. Dr. Nassar and is rated as an Experienced provider by MediFind in the treatment of Systemic Capillary Leak Syndrome. Her top areas of expertise are Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis, Factor V Leiden Thrombophilia, and Pulmonary Fibrosis.

 
 
 
 
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Dr. Jason R. Michaels
Dermatology
Dr. Jason R. Michaels
Dermatology

Aspire Dermatology LLC

102 Valley Rd, 
Middletown, RI 
 (22.2 mi)
401-239-1800
Languages Spoken:
English
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Jason Michaels is a Dermatologist in Middletown, Rhode Island. Dr. Michaels and is rated as an Advanced provider by MediFind in the treatment of Systemic Capillary Leak Syndrome. His top areas of expertise are Plaque Psoriasis, Autoerythrocyte Sensitivity, Gardner-Diamond Syndrome, and Purpura.

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What are the latest Systemic Capillary Leak Syndrome Clinical Trials?
Phase II Randomized Study Evaluating a Pragmatic Approach to Adoptive Cell Therapy (ACT) Using an IL2 Analog (ANV419) vs High Dose IL2 After Tumor Infiltrating Lymphocytes (TIL) Therapy in Patients With Melanoma, NSCLC and Cervical Cancer
Phase II Randomized Study Evaluating a Pragmatic Approach to Adoptive Cell Therapy (ACT) Using an IL2 Analog (ANV419) vs High Dose IL2 After Tumor Infiltrating Lymphocytes (TIL) Therapy in Patients With Melanoma, NSCLC and Cervical Cancer
Enrollment Status: Recruiting
Publish Date: January 28, 2025
Intervention Type: Biological
Study Phase: Phase 2

Background: The presence of T-lymphocytes in resected tumor samples derived from long-term survival patients and the fact that reinvigoration of their functionality through the administration of specific immune-therapies can lead to remarkable antitumor responses supports that lymphocytes play a critical role in cancer immunity. TIL-based ACT (Adoptive cell therapy using tumor-infiltrating lymphocytes product...

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center