Thrombocytopenia Overview
Learn About Thrombocytopenia
Thrombocytopenia means there is an abnormally low amount of platelets. Platelets are parts of the blood that help blood to clot. This condition is sometimes associated with abnormal bleeding.
Low platelet count - thrombocytopenia
Thrombocytopenia is often divided into 3 major causes of low platelets:
- Not enough platelets are made in the bone marrow
- Increased removal of platelets in the bloodstream
- Increased trapping of platelets in the spleen or liver
Your bone marrow may not make enough platelets if you have any of the following conditions:
- Aplastic anemia (disorder in which the bone marrow does not make enough blood cells)
- Cancer in the bone marrow, such as leukemia
- Cirrhosis (liver scarring)
- Folate deficiency
- Infections in the bone marrow (very rare)
- Myelodysplastic syndrome (bone marrow does not make enough blood cells or makes defective cells)
- Vitamin B12 deficiency
Use of certain medicines may also lead to a low production of platelets in the bone marrow. The most common example is chemotherapy treatment for cancer.
The following health situations cause a low number of platelets:
- Disorder in which the proteins that control blood clotting become over active, most often during a serious illness (disseminated intravascular coagulation - DIC)
- Drug-induced low platelet count
- Enlarged spleen
- Disorder in which the immune system destroys platelets (immune thrombocytopenic purpura - ITP)
- Disorder that causes blood clots to form in small blood vessels, causing a low platelet count (thrombotic thrombocytopenic purpura - TTP)
You may not have any symptoms. Or you may have general symptoms, such as:
- Bleeding in the mouth and gums
- Bruising
- Nosebleeds
- Rash
Other symptoms depend on the cause.
Treatment depends on the cause of the condition. In some cases, a transfusion of platelets may be required to stop or prevent bleeding.
Mercy Clinic Oklahoma Communities
Christopher Thompson is a Hematologist Oncology specialist and a Hematologist in Oklahoma City, Oklahoma. Dr. Thompson and is rated as a Distinguished provider by MediFind in the treatment of Thrombocytopenia. His top areas of expertise are Thrombocytopenia, Chronic Familial Neutropenia, Agranulocytosis, Febrile Neutropenia, and Bone Marrow Aspiration. Dr. Thompson is currently accepting new patients.
Mercy Clinic Oklahoma Communities
Abby Bova is a Hematologist Oncology specialist and a Hematologist in Oklahoma City, Oklahoma. Dr. Bova and is rated as a Distinguished provider by MediFind in the treatment of Thrombocytopenia. Her top areas of expertise are Paget Disease of the Breast, Breast Cancer, Angiosarcoma, Inflammatory Breast Cancer, and Bone Marrow Aspiration. Dr. Bova is currently accepting new patients.
Mercy Clinic Oklahoma Communities
Joseph Jamison is a Family Medicine provider in Edmond, Oklahoma. Dr. Jamison and is rated as an Experienced provider by MediFind in the treatment of Thrombocytopenia. His top areas of expertise are Macroamylasemia, Type 2 Diabetes (T2D), Glucocorticoid-Remediable Aldosteronism, and Familial Hypertension. Dr. Jamison is currently accepting new patients.
The outcome depends on the disorder causing the low platelet counts.
Severe bleeding (hemorrhage) is the main complication. Bleeding may occur in the brain or gastrointestinal tract.
Contact your provider if you experience unexplained bleeding or bruising.
Prevention depends on the specific cause.
Summary: This study will evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of ravulizumab in adult and adolescent participants with hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA). In Stage 1, an open-label, single-arm period, the dosing regimen will be confirmed. In Stage 2, participants will be randomized to receive either blinded ravulizumab plus b...
Summary: The objectives of this study are to evaluate the efficacy, safety, and pharmacokinetics of INM004 in pediatric patients with Hemolytic Uremic Syndrome associated to infection by Shiga toxin-producing Escherichia coli (STEC-HUS).
Published Date: March 31, 2024
Published By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Abrams CS. Thrombocytopenia. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 158.
Branchford BR, Samelson-Jones BJ, Flood VH. Platelet and blood vessel disorders. In: Kliegman RM, St. Geme JW, Blum NJ, eds. Nelson Textbook of Pediatrics. 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 533.
Warkentin TE. Thrombocytopenia caused by hypersplenism, platelet destruction, or surgery/hemodilution. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 130.
Zeller MP, Ning S, Arnold DM, Gabe C. Diseases of platelet number: immune thrombocytopenia, neonatal alloimmune thrombocytopenia, and posttransfusion purpura. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 129.