Type A Insulin Resistance Syndrome Overview
Learn About Type A Insulin Resistance Syndrome
Type A insulin resistance syndrome is a rare disorder characterized by severe insulin resistance, a condition in which the body's tissues and organs do not respond properly to the hormone insulin. Insulin normally helps regulate blood sugar levels by controlling how much sugar (in the form of glucose) is passed from the bloodstream into cells to be used as energy. In people with type A insulin resistance syndrome, insulin resistance impairs blood glucose regulation and ultimately leads to a condition called diabetes mellitus, in which blood glucose levels can become dangerously high.
Type A insulin resistance syndrome results from mutations in the INSR gene. This gene provides instructions for making a protein called an insulin receptor, which is found in many types of cells. Insulin receptors are embedded in the outer membrane surrounding the cell, where they attach (bind) to insulin circulating in the bloodstream. This binding triggers signaling pathways that influence many cell functions.
Type A insulin resistance syndrome is estimated to affect about 1 in 100,000 people worldwide. Because females have more health problems associated with the condition, it is diagnosed more often in females than in males.
Type A insulin resistance syndrome can have either an autosomal dominant or, less commonly, an autosomal recessive pattern of inheritance.
Florida Post Acute Care Clinicians LLC
Angela Crawford is a General Surgeon and a Physician Assistant in North Miami Beach, Florida. Crawford has been practicing medicine for over 12 years and is rated as an Experienced provider by MediFind in the treatment of Type A Insulin Resistance Syndrome. Her top areas of expertise are Peptic Ulcer, Necrosis, Cellulitis, and Stasis Dermatitis and Ulcers.
Health Holdings Company LLC
Jennifer Capezzuti is a Family Medicine provider in Parkland, Florida. Dr. Capezzuti and is rated as an Experienced provider by MediFind in the treatment of Type A Insulin Resistance Syndrome. Her top areas of expertise are Type A Insulin Resistance Syndrome, Acanthosis Nigricans, Osteomyelitis in Children, and High Cholesterol. Dr. Capezzuti is currently accepting new patients.
Orlando Health Medical Group Inc
Priya Patel is an Internal Medicine provider in Ocoee, Florida. Dr. Patel and is rated as an Experienced provider by MediFind in the treatment of Type A Insulin Resistance Syndrome. Her top areas of expertise are Sepsis, Pneumonia, Familial Neurocardiogenic Syncope, Bone Graft, and Vertebroplasty.
Objectives: To correlate moderate to severe acanthosis nigricans with diabetes complication Methodology: T2DM patient will be recruited from endocrine OPD 1. Clinical History and Examination: 1. General Physical Examination: Height, weight, waist circumference, hip circumference, BMI, Blood Pressure, Hand grip. Acanthosis Nigricans. 2. Complications Assessment: Patient will be analysed for: Micro Vascular (a)...
Summary: To test these hypotheses, The Investigators will recruit 100 overweight and obese adolescents with HbA1c ranging across the ADA classification spectrum from normal to prediabetes,(nearly 40:normoglycemi, 30: IFG, 30:1GT) measure free-living glucose by continuous glucose monitoring (CGM), and assess the relationships among CGM outcomes, HbA1c, and OGTT results (FPG and 2-h glucose). Individual with...
Published Date: December 01, 2014
Published By: National Institutes of Health