Undifferentiated Pleomorphic Sarcoma Overview

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Learn About Undifferentiated Pleomorphic Sarcoma

What is the definition of Undifferentiated Pleomorphic Sarcoma?
Undifferentiated pleomorphic sarcoma (UPS), also known as malignant fibrous histiocytoma, is a rare, aggressive soft tissue or bone cancer that usually occurs in the arms or legs in the sixth or seventh decade of life.
What are the symptoms of Undifferentiated Pleomorphic Sarcoma?
Symptoms of undifferentiated pleomorphic sarcoma may include the presence of a mostly painless, rapidly enlarging nodule in the lower extremities (especially the thigh), upper arms, head and neck, retroperitoneum, viscera, distal or proximal femur (upper leg), proximal tibia (lower leg), or humerus (upper arm). Additional symptoms of undifferentiated pleomorphic sarcoma may include pain, swelling, malaise, lack of appetite, constipation, fever, and weight loss.
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What are the current treatments for Undifferentiated Pleomorphic Sarcoma?
Treatment for undifferentiated pleomorphic sarcoma depends on the location but may include surgery, radiation therapy, chemotherapy (ifosfamide, trabectedin, dacarbazine, and pazopanib), targeted therapy, and immunotherapy.
Who are the top Undifferentiated Pleomorphic Sarcoma Local Doctors?
Advanced in Undifferentiated Pleomorphic Sarcoma
Dr. Kenneth R. Manning
Oncology
Advanced in Undifferentiated Pleomorphic Sarcoma
Dr. Kenneth R. Manning
Oncology

Cumberland County Hospital System Inc

1638 Owen Dr, 
Fayetteville, NC 
 (24.4 mi)
910-615-5610
Languages Spoken:
English, Spanish
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Kenneth Manning is an Oncologist in Fayetteville, North Carolina. Dr. Manning and is rated as an Advanced provider by MediFind in the treatment of Undifferentiated Pleomorphic Sarcoma. His top areas of expertise are Breast Cancer, Paget Disease of the Breast, Inflammatory Breast Cancer, and Angiosarcoma. Dr. Manning is currently accepting new patients.

Experienced in Undifferentiated Pleomorphic Sarcoma
Dr. Mark H. Moriarty
Orthopedics
Experienced in Undifferentiated Pleomorphic Sarcoma
Dr. Mark H. Moriarty
Orthopedics

Sampson Regional Professional Services LLC

607 Beaman St, 
Clinton, NC 
 (10.2 mi)
Languages Spoken:
English
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Accepting New Patients
Offers Telehealth

Mark Moriarty is an Orthopedics provider in Clinton, North Carolina. Dr. Moriarty and is rated as an Experienced provider by MediFind in the treatment of Undifferentiated Pleomorphic Sarcoma. His top areas of expertise are Osteoarthritis, Tendinitis, Tenosynovitis, Carpal Tunnel Syndrome, and Hip Replacement. Dr. Moriarty is currently accepting new patients.

 
 
 
 
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Experienced in Undifferentiated Pleomorphic Sarcoma
Dr. Tariq Nazir
Hematology Oncology | Hematology | Oncology
Experienced in Undifferentiated Pleomorphic Sarcoma
Dr. Tariq Nazir
Hematology Oncology | Hematology | Oncology

Cumberland County Hospital System Inc

6387 Ramsey St, Unit 100, 
Fayetteville, NC 
 (23.0 mi)
910-615-3879
Languages Spoken:
English, Spanish
See accepted insurances
Accepting New Patients
Offers Telehealth

Tariq Nazir is a Hematologist Oncology specialist and a Hematologist in Fayetteville, North Carolina. Dr. Nazir and is rated as an Experienced provider by MediFind in the treatment of Undifferentiated Pleomorphic Sarcoma. His top areas of expertise are Pleuropulmonary Blastoma, Lung Cancer, Familial Colorectal Cancer, and Colorectal Cancer. Dr. Nazir is currently accepting new patients.

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What are the latest Undifferentiated Pleomorphic Sarcoma Clinical Trials?
A Randomized Phase III Trial of Doxorubicin + Pembrolizumab Versus Doxorubicin Alone for the Treatment of Undifferentiated Pleomorphic Sarcoma (UPS) and Related Poorly Differentiated Sarcomas
A Randomized Phase III Trial of Doxorubicin + Pembrolizumab Versus Doxorubicin Alone for the Treatment of Undifferentiated Pleomorphic Sarcoma (UPS) and Related Poorly Differentiated Sarcomas
Enrollment Status: Recruiting
Publish Date: February 24, 2025
Intervention Type: Procedure, Drug, Biological
Study Phase: Phase 3

Summary: This phase II trial compares the effect of immunotherapy (pembrolizumab) plus chemotherapy (doxorubicin) to chemotherapy (doxorubicin) alone in treating patients with undifferentiated pleomorphic sarcoma (UPS) or a related poorly differentiated sarcoma that has spread from where it first started (primary site) to other places in the body (metastatic) or that cannot be removed by surgery (unresecta...

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Focused Ultrasound to Promote Immune Responses for Undifferentiated Pleomorphic Sarcoma
Focused Ultrasound to Promote Immune Responses for Undifferentiated Pleomorphic Sarcoma
Enrollment Status: Recruiting
Publish Date: January 31, 2025
Intervention Type: Device
Study Phase: Not Applicable

Summary: This study is a single site, single-arm, feasibility study to evaluate the safety and efficacy of MRgFUS using the ExAblate 2100 System for the partial ablation of undifferentiated pleomorphic sarcomas.

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