VEXAS Syndrome Overview

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Learn About VEXAS Syndrome

What is the definition of VEXAS Syndrome?
VEXAS syndrome is a severe inflammatory syndrome caused by a genetic mutation in bone marrow.
What are the symptoms of VEXAS Syndrome?
Symptoms of VEXAS syndrome usually occur between 45 and 80 years of age and may include recurrent fevers, inflammation of the blood vessels, fluid and infections in the lungs, skin and eye inflammation, deep vein clots, joint pain, infections of the cartilage of the ear and nose, anemia, and sensorineural hearing loss.
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What are the current treatments for VEXAS Syndrome?
There is currently no standard treatment for VEXAS syndrome. However, glucocorticoids have provided some symptom relief. Researchers are currently investigating bone marrow transplants and gene editing as possible treatments for VEXAS syndrome.
Who are the top VEXAS Syndrome Local Doctors?
Elite in VEXAS Syndrome
Mael Heiblig
Elite in VEXAS Syndrome
Mael Heiblig
Pierre-la-treiche, FR 

Mael Heiblig practices in Pierre-la-treiche, France. Mr. Heiblig is rated as an Elite expert by MediFind in the treatment of VEXAS Syndrome. His top areas of expertise are VEXAS Syndrome, Acute Myeloid Leukemia (AML), Leukemia, Myelodysplastic Syndrome (MDS), and Bone Marrow Transplant.

Elite in VEXAS Syndrome
Arsene M. Mekinian
Elite in VEXAS Syndrome
Arsene M. Mekinian
Paris, FR 

Arsene Mekinian practices in Paris, France. Mr. Mekinian is rated as an Elite expert by MediFind in the treatment of VEXAS Syndrome. His top areas of expertise are VEXAS Syndrome, Takayasu Arteritis, Vasculitis, Antiphospholipid Syndrome, and Intrauterine Device Insertion.

 
 
 
 
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Elite in VEXAS Syndrome
Vincent Jachiet
Elite in VEXAS Syndrome
Vincent Jachiet
Paris, FR 

Vincent Jachiet practices in Paris, France. Mr. Jachiet is rated as an Elite expert by MediFind in the treatment of VEXAS Syndrome. His top areas of expertise are VEXAS Syndrome, Chronic Myelomonocytic Leukemia (CMML), Myelodysplastic Syndrome (MDS), and Hypereosinophilic Syndrome.

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What are the latest VEXAS Syndrome Clinical Trials?
A Single-arm Phase II With safety-run-in Multicenter Study of Momelotinib in Patients With VEXAS Syndrome With or Without Associated Myelodysplastic Syndrome
A Single-arm Phase II With safety-run-in Multicenter Study of Momelotinib in Patients With VEXAS Syndrome With or Without Associated Myelodysplastic Syndrome
Enrollment Status: Recruiting
Publish Date: December 10, 2025
Intervention Type: Drug
Study Phase: Phase 2

Summary: Multicenter, phase II trial with safety run-in to evaluate the efficacy and safety of momelotinib in patients with VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory and Somatic) syndrome with or without associated myelodysplastic syndrome (MDS). The study will consist of two consecutive steps, a dose-finding safety run-in and a single-arm prospective phase II. During safety run-in phase, thre...

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A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects With VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects With VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Who is this study for: Patients with VEXAS syndrome
Enrollment Status: Recruiting
Publish Date: November 26, 2025
Intervention Type: Procedure, Drug, Radiation
Study Drugs: Post-Transplant Cyclophosphamide, Cyclophosphamide, Fludarabine, Busulfan, Sirolimus, Mycophenolate mofetil, Busulfan
Study Phase: Phase 2

Background: Allogeneic hematopoietic stem cell transplant involves taking blood stem cells from a donor and giving them to a recipient. The transplants are used to treat certain diseases and cancers. Researchers want to see if the transplant can treat VEXAS Syndrome.

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