Learn About Anaplastic Thyroid Cancer

View Main Condition: Thyroid Cancer

What is the definition of Anaplastic Thyroid Cancer?

Anaplastic thyroid carcinoma is a rare and aggressive form of cancer of the thyroid gland.

What are the alternative names for Anaplastic Thyroid Cancer?

Anaplastic carcinoma of the thyroid

What are the causes of Anaplastic Thyroid Cancer?

Anaplastic thyroid cancer is an invasive type of thyroid cancer that grows very rapidly. It occurs most often in people over age 60. It is more common in females than in males. The cause is unknown.

Anaplastic cancer accounts for only about less than 1% of all thyroid cancers in the United States.

What are the symptoms of Anaplastic Thyroid Cancer?

Symptoms include:

  • Cough
  • Coughing up blood
  • Difficulty swallowing
  • Hoarseness or changing voice
  • Loud breathing
  • Lower neck lump, which often grows quickly
  • Pain in the neck
  • Vocal cord paralysis
  • Overactive thyroid (hyperthyroidism)
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What are the current treatments for Anaplastic Thyroid Cancer?

This type of cancer cannot be cured by surgery.

Surgery combined with radiation therapy and chemotherapy may have a significant benefit.

Surgery to place a tube in the throat to help with breathing (tracheostomy) or in the stomach to help with eating (gastrostomy) may be needed during treatment.

For some people, enrolling in a clinical trial of new thyroid cancer treatments based on the genetic changes in the tumor may be an option.

The presence of a mutation in the BRAF gene is treatable with targeted medicines and may improve outcomes.

Who are the top Anaplastic Thyroid Cancer Local Doctors?
Otolaryngology
Otolaryngology
12502 Willowbrook Rd, 
Cumberland, MD 
 19.2 mi

David Litman is an Otolaryngologist in Cumberland, Maryland. Dr. Litman and is rated as an Advanced provider by MediFind in the treatment of Anaplastic Thyroid Cancer. His top areas of expertise are Thyroid Nodule, Acinic Cell Carcinoma of Salivary Glands, Salivary Gland Tumors, Gastrostomy, and Thyroidectomy.

Neuromusculoskeletal Medicine | Endocrinology
Neuromusculoskeletal Medicine | Endocrinology
220 Baltimore Ave, 
Cumberland, MD 
 18.6 mi

Heather Peirce is a Neuromusculoskeletal Medicine specialist and an Endocrinologist in Cumberland, Maryland. Dr. Peirce has been practicing medicine for over 46 years and is rated as an Advanced provider by MediFind in the treatment of Anaplastic Thyroid Cancer. Her top areas of expertise are Obesity in Children, Hypothyroidism, Thyroid Nodule, and Type 2 Diabetes (T2D).

 
 
 
 
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Endocrinology
Endocrinology

Upmc Western Maryland Health Services LLC

12502 Willowbrook Rd, 
Cumberland, MD 
 19.2 mi
Accepting New Patients

Smriti Manandhar is an Endocrinologist in Cumberland, Maryland. Dr. Manandhar and is rated as an Advanced provider by MediFind in the treatment of Anaplastic Thyroid Cancer. Her top areas of expertise are Obesity in Children, Hypothyroidism, Hyperthyroidism, and Familial Isolated Hyperparathyroidism. Dr. Manandhar is currently accepting new patients.

What are the support groups for Anaplastic Thyroid Cancer?

You can often ease the stress of illness by joining a support group of people sharing common experiences and problems.

What is the outlook (prognosis) for Anaplastic Thyroid Cancer?

The outlook with this disease is poor. Most people do not survive longer than 6 months because the disease is aggressive and there is a lack of effective treatment options.

What are the possible complications of Anaplastic Thyroid Cancer?

Complications may include:

  • Spread of tumor within the neck
  • Metastasis (spread) of cancer to other body tissues or organs
When should I contact a medical professional for Anaplastic Thyroid Cancer?

Contact your health care provider if you notice:

  • A persistent lump or mass in the neck
  • Hoarseness or changes in your voice
  • Cough or coughing up blood
What are the latest Anaplastic Thyroid Cancer Clinical Trials?
A Multicenter, Open Label, Two Cohort, Single Arm, Phase II Study to Evaluate the Efficacy and Safety of the Anti-TROP2 Antibody-drug Conjugate Sacituzumab Govitecan in Patients With Advanced Differentiated and Anaplastic Thyroid Neoplasms.

Summary: SETHY is a prospective, multicohort, phase II, single-arm, non-randomized, non-blinded, investigator-initiated study of sacituzumab govitecan in patients with advanced or metastatic radioactive-iodine refractory differentiated thyroid carcinoma (DTC) or anaplastic thyroid carcinoma (ATC). The main hypothesis is that treatment with sacituzumab govitecan, a anti-Trophoblast cell surface antigen 2 (T...

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Restoration of Radioiodine Uptake with Selpercatinib in RET Fusion-Positive Radioiodine-Refractory Thyroid Cancer: a Phase 2 Study Performed in Collaboration with the International Thyroid Oncology Group (ITOG)

Summary: This research is being done to determine the efficacy of selpercatinib to restore radioactive iodine (I-131 NaI) uptake and allow for I-131 treatment in people with RET fusion-positive radioiodine-refractory thyroid cancer. This research study involves the study drug selpercatinib in combination with standard of care treatments, I-131 and thyrotropin alfa (rhTSH).

What are the Latest Advances for Anaplastic Thyroid Cancer?
Rationale Efficacy and Safety Evidence of Lenvatinib and Pembrolizumab Association in Anaplastic Thyroid Carcinoma.
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Phase II study of the efficacy and safety of lenvatinib for anaplastic thyroid cancer (HOPE).
Who are the sources who wrote this article ?

Published Date: March 31, 2024
Published By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Bible KC, Kebebew E, Brierley J, et al. 2021 American Thyroid Association guidelines for management of patients with anaplastic thyroid cancer. Thyroid. 2021;31(3):337-386. PMID: 33728999 pubmed.ncbi.nlm.nih.gov/33728999/.

National Cancer Institute. Anaplastic thyroid cancer (ATC). www.cancer.gov/pediatric-adult-rare-tumor/rare-tumors/rare-endocrine-tumor/anaplastic-thyroid-cancer. Updated February 27, 2019. Accessed May 3, 2024.

Pearce EN, Hollenberg AN. Thyroid. In: Goldman L, Cooney KA. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 207.

Suh I, Sosa JA. Thyroid. In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 21st ed. St Louis, MO: Elsevier; 2022:chap 37.