Adult T-Cell Leukemia Overview

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Learn About Adult T-Cell Leukemia

View Main Condition: Leukemia

What is the definition of Adult T-Cell Leukemia?
Adult T-cell leukemia/lymphoma (ATL) is is a rare and aggressive T-cell lymphoma that is linked to infection by the human T-cell lymphotropic virus 1 (HTLV-1). The exact mechanism by which HTLV-I infection causes the ATL is unknown. The clinical features of ATL include generalized swelling of the lymph nodes (lymphadenopathy), increased liver and spleen size (hepatosplenomegaly), immunosuppression, high levels of calcium in the blood, lytic bone lesions (spots that appear as 'holes' on a standard bone x-ray), and skin lesions. There are four basic clinical variants of ATL: acute (60% of cases), lymphomatous (20 % of cases), chronic (10% of cases) and smoldering (10% of cases).
What are the alternative names for Adult T-Cell Leukemia?
  • Adult T-cell leukemia/lymphoma
  • ATLL
  • Adult T-cell leukaemia
  • Adult T-cell leukaemia/lymphoma (HTLV-1 positive)
  • Adult T-cell lymphoma
Who are the top Adult T-Cell Leukemia Local Doctors?
Dr. Patti B. Wheeler
Family Medicine
Dr. Patti B. Wheeler
Family Medicine

Mission Health Community Multispecialty Providers LLC

509 Biltmore Ave, 
Asheville, NC 
 (1.4 mi)
828-213-2325
Languages Spoken:
English
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Accepting New Patients
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Patti Wheeler is a Family Medicine provider in Asheville, North Carolina. Dr. Wheeler and is rated as an Experienced provider by MediFind in the treatment of Adult T-Cell Leukemia. Her top areas of expertise are Opisthotonos, Muscle Spasms, Sciatica, and Hypothyroidism. Dr. Wheeler is currently accepting new patients.

Dr. Michael J. Messino
Hematology Oncology | Hematology | Oncology
Dr. Michael J. Messino
Hematology Oncology | Hematology | Oncology
551 Brevard Rd, 
Asheville, NC 
 (4.2 mi)
828-212-7021
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Michael Messino is a Hematologist Oncology specialist and a Hematologist in Asheville, North Carolina. Dr. Messino and is rated as an Experienced provider by MediFind in the treatment of Adult T-Cell Leukemia. His top areas of expertise are Colorectal Cancer, Breast Cancer, Paget Disease of the Breast, Gliosarcoma, and Bone Marrow Aspiration. Dr. Messino is currently accepting new patients.

 
 
 
 
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Dr. William C. Ballantine
Internal Medicine
Dr. William C. Ballantine
Internal Medicine

Blue Ridge Premier Medicine PLLC

70 Peachtree Rd, Suite 230, 
Asheville, NC 
 (4.7 mi)
828-277-6789
Languages Spoken:
English
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Accepting New Patients
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William Ballantine is an Internal Medicine provider in Asheville, North Carolina. Dr. Ballantine and is rated as an Experienced provider by MediFind in the treatment of Adult T-Cell Leukemia. His top areas of expertise are Melorheostosis with Osteopoikilosis, Melorheostosis, Osteopenia, and Chronic T-Cell Leukemia (CTCL). Dr. Ballantine is currently accepting new patients.

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What are the latest Adult T-Cell Leukemia Clinical Trials?
A Pilot Trial to Evaluate Next-Generation Sequencing (NGS) Testing and Monitoring of B-Cell Recovery to Guide Management Following CAR T-cell Induced Remission in Pediatric Patients With B Lineage Acute Lymphoblastic Leukemia
A Pilot Trial to Evaluate Next-Generation Sequencing (NGS) Testing and Monitoring of B-Cell Recovery to Guide Management Following CAR T-cell Induced Remission in Pediatric Patients With B Lineage Acute Lymphoblastic Leukemia
Enrollment Status: Recruiting
Publish Date: February 26, 2025
Intervention Type: Diagnostic test
Study Phase: Not Applicable

Background: Chimeric antigen receptor T-cell (CART) therapy is a form of immunotherapy which can be used to treat people with relapsed B-ALL. For those who achieve remission after CART alone, it may cure up to 50% of people who receive this therapy. However, for people who relapse after CART, it can be hard to achieve remission again. In patients where CART fails, stem cell transplant (HCT) can be used to pre...

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A Pilot Phase I Trial of IL-21 Expanded, Off the Shelf, Third-Party Natural Killer (NK) Cells in Combination with Mogamulizumab in Patients with Cutaneous T-Cell Lymphomas or Adult T-Cell Leukemia/Lymphomas
A Pilot Phase I Trial of IL-21 Expanded, Off the Shelf, Third-Party Natural Killer (NK) Cells in Combination with Mogamulizumab in Patients with Cutaneous T-Cell Lymphomas or Adult T-Cell Leukemia/Lymphomas
Who is this study for: Patients with Lymphoma
Enrollment Status: Recruiting
Publish Date: February 25, 2025
Intervention Type: Other, Drug, Biological
Study Drugs: Cyclophosphamide, Fludarabine, Mogamulizumab, Natural Killer Cell Therapy
Study Phase: Phase 1

Summary: This phase I trial is to find out the best dose, possible benefits and/or side effects of third-party natural killer cells in combination with mogamulizumab in treating patients with cutaneous T-cell lymphoma or adult T-cell leukemia/lymphoma that has come back (relapsed) or does not respond to treatment (refractory). Immunotherapy with third-party natural killer cells, may induce changes in body'...

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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center