Lymphoid Malignancies and Precursors: Tissue Acquisition Protocol
Background: - Lab studies help researchers better understand cancer biology. This information may lead to new methods for diagnosing or treating cancer. To develop these studies, researchers want to collect samples from people with cancer or precancer conditions of the lymph system. These conditions include multiple myeloma, different types of lymphoma, and adult leukemia/lymphoma. The samples collected will include blood, urine, bone marrow, and tumor and skin tissue.
Objectives: - To collect tissue samples to study different types of lymph cancer.
Eligibility: - Individuals at least 18 years of age who have a lymphoid cancer or precancer condition.
Design: * Participants will be screened with a physical exam and medical history. * Different samples will be collected for study. Blood samples will be collected at the initial testing. More blood samples will be collected at different treatment points. Other liquid samples include urine, bone marrow, and any abnormal fluid. Tumor tissue and skin tissue biopsies will also be collected for study. * Treatment will not be provided as part of this study.
⁃ Patients with a known lymphoid malignancy or precursor disease to a lymphoid malignancy, including multiple myeloma, B-cell and T-cell lymphomas: including but not limited to diffuse large B-cell lymphoma (DLBCL), Hodgkin s lymphoma (HL), multiple myeloma (MM), lymphomatoid granulomatosis (LYG) and adult T-cell leukemia/lymphoma (ATL).
⁃ Confirmation of pathological diagnosis is required from the Laboratory of Pathology, NCI. Tumor tissue that has been previously collected and is available for study or that can be collected with minimal additional risk to the subject during sampling required for routine patient care or required testing on an NIH research protocol will be used for diagnosis.
⁃ Age \>= 18 years of age
⁃ ECOG performance 0-2
⁃ Ability of patient or Legally Authorized Representative (LAR) to understand and the willingness to sign a written informed consent document NOTE: Patients enrolling with a LAR must be co-enrolled on another study.
‣ INCLUSION FOR APHERESIS:
‣ NOTE: This is optional in all patients and will only be requested if the patient is willing, timing allows, and the following criteria are met.
⁃ Hemoglobin \>= 10 mg/dL and platelet count \> 75 K/uL
⁃ Weight greater than 25 kg
⁃ HIV negative
⁃ Prothrombin Time - within normal limits
⁃ Partial Thromboplastin Time - within normal limits
⁃ Medically indicated central line in place or adequate peripheral venous access
• Patients without a known lymphoid malignancy or lymphoid precursor diagnosis who have a planned surgical procedure during which blood or normal lymph node(s)/tissue (i.e., those not with pre-determined likelihood of abnormality/ malignancy) may be obtained for research studies as part of this protocol
‣ Patient is appropriate to undergo the surgical procedure planned, and consented for the same, as needed. NOTE: This study will not evaluate eligibility of the patient for surgery.
⁃ Age \>= 18 years of age
⁃ Must be able and willing to sign informed consent